Phosphine, (4-chlorophenyl)diphenyl- synthesis
- Product Name:Phosphine, (4-chlorophenyl)diphenyl-
- CAS Number:734-60-1
- Molecular formula:C18H14ClP
- Molecular Weight:296.73
Yield:734-60-1 81%
Reaction Conditions:
with potassium acetate in N,N-dimethyl acetamide at 130; for 3 h;Schlenk technique;Inert atmosphere;
Steps:
9 2.3. General procedure for C-P coupling reaction of various aryliodides with diphenylphosphine
General procedure: MCM-41-3N-Pd(0) (21mg, 0.01mmol), KOAc (1.5mmol) and aryl iodide 1 (1.0mmol) (if solid) were placed in an oven-dried 20mL Schlenk tube, the reaction vessel was evacuated and filled with argon for three times. Then aryl iodide 1 (1.0mmol) (if liquid), diphenylphosphine (1.2mmol) and DMAc (1mL) were added with a syringe under a counter flow of argon. The reaction mixture was stirred at 130°C for 3h. After completion of the reaction, the mixture was cooled to room temperature and diluted with CH2Cl2 (20mL) and filtered. The MCM-41-3N-Pd(0) catalyst was washed with distilled water (2×5mL) and ethanol (2×5mL), and reused in the next run. The filtrate was concentrated in vacuo and the residue was purified by flash column chromatography on silica gel to provide the product 2.
References:
Xu, Zhaotao;Wang, Pingping;Chen, Qiurong;Cai, Mingzhong [Journal of Organometallic Chemistry,2018,vol. 866,p. 50 - 58]
