ChemicalBook CAS DataBase List PLERIXAFOR

PLERIXAFOR synthesis

5synthesis methods

Product Name:PLERIXAFOR
CAS Number:110078-46-1
Molecular formula:C28H54N8
Molecular Weight:502.78

Plerixafor can be synthesized by several related procedures starting from tetraazacyclotetradecane, the macrocyclic tetraamine cyclam. The general synthetic strategy entails the masking of three of the four ring nitrogens, followed by alkylation with para-xylylene dibromide, and subsequent removal of the masking groups. In one approach, tetraazacyclotetradecane is protected as the phosphorotriamide derivative by reaction with tris (dimethylamino)phosphine followed by oxidation with carbon tetrachloride and sodium hydroxide. After condensation with xylylene dibromide, the dimeric bis-phosphoramide intermediate is hydrolyzed to plerixafor by treatment with dilute hydrochloric acid solution.

623-24-5 Synthesis

623-24-5
327 suppliers
$6.00/1g

110078-46-1
277 suppliers
$19.00/5mg

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylMethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

406939-93-3
15 suppliers
$160.00/2.5mg

110078-46-1
277 suppliers
$19.00/5mg

References

592516-98-8
1 suppliers
inquiry

110078-46-1
277 suppliers
$19.00/5mg

References

623-24-5 Synthesis

623-24-5
327 suppliers
$6.00/1g

295-37-4 Synthesis

295-37-4
309 suppliers
$18.00/250mg

110078-46-1
277 suppliers
$19.00/5mg

References

1,4,8,11-Tetraazacyclotetradecane-1,4,8-tricarboxylic acid, 11,11'-[1,4-phenylenebis(methylene)]bis-, hexakis(1,1-dimethylethyl) ester (9CI)

175854-48-5
1 suppliers
inquiry

110078-46-1
277 suppliers
$19.00/5mg

References

PLERIXAFOR Related Search:

Varenicline tartrate GSK-3BETA INHIBITOR XII Enzalutamide Gefitinib Nintedanib esylate Alectinib Hydrochloride 1,4,8,11-TETRAAZACYCLOTETRADECANE

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.