Pyrazinecarbonyl chloride, 5-chloro- (9CI) synthesis
- Product Name:Pyrazinecarbonyl chloride, 5-chloro- (9CI)
- CAS Number:88625-23-4
- Molecular formula:C5H2Cl2N2O
- Molecular Weight:176.99
36070-80-1
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Yield: 100%
Reaction Conditions:
with (COCl)2;N-methyl-acetamide in dichloromethane
Steps:
Preparation of Starting Material 5-chloro-N,N-dimethylpyrazine-2-carboxamide (SM-1)
Preparation of Starting Material 5-chloro-N,N-dimethylpyrazine-2-carboxamide (SM-1) 5-chloropyrazine-2-carboxylic acid (1.00 gram, 6.31 mmol) in dichloromethane (30 ml) was treated with catalytic amount of dimethylformamide, followed by (COCl)2 (0.85 ml, 9.46 mmol). The resulting mixture was stirred over night. The reaction was concentrated in vacuo, and dried under vacuum to give desired 5-chloropyrazine-2-carbonyl chloride as solid (1.05 g, 100%).
References:
Pfizer Inc US2010/234285, 2010, A1
34604-60-9
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88625-23-4
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34604-60-9
205 suppliers
$15.00/1g
88625-23-4
18 suppliers
inquiry
79-37-8
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$17.67/10gm:
36070-80-1
276 suppliers
$9.00/1g
88625-23-4
18 suppliers
inquiry