Pyridine, 3-(2S)-oxiranyl- (9CI) synthesis
- Product Name:Pyridine, 3-(2S)-oxiranyl- (9CI)
- CAS Number:329281-07-4
- Molecular formula:C7H7NO
- Molecular Weight:121.14
391902-10-6
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Yield:329281-07-4 42%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran;water monomer at 20; for 1 h;
Steps:
35
To a solution of (S)-2-Bromo-1-pyridin-3-yl-ethanol (134 mg, 0.66 mmol) in THF (10 mL) was added 4N NaOH solution (8.3 mL). The reaction mixture was stirred at room temperature for 1 h. The organic phase was separated, dried over Na2SO4 and concentrated. Silica gel prep TLC of the resulting residue using 99:1 CH2Cl2:MeOH as an eluant afforded 34 mg of (S)-3-Oxiranyl-pyridine as a colorless oil (42%).
References:
US2006/25433,2006,A1 Location in patent:Page/Page column 121
17694-68-7
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350-03-8
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329281-07-4
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