Pyridine, 4-bromo-2-phenoxy- synthesis
- Product Name:Pyridine, 4-bromo-2-phenoxy-
- CAS Number:1353776-73-4
- Molecular formula:C11H8BrNO
- Molecular Weight:250.09
58530-53-3
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108-95-2
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1353776-73-4
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Yield:1353776-73-4 98%
Reaction Conditions:
with copper(l) iodide;N,N,N,N,-tetramethylethylenediamine;caesium carbonate in dimethyl sulfoxide at 110; for 24 h;Inert atmosphere;regioselective reaction;Reagent/catalyst;Solvent;
Steps:
4.1 General procedure for the copper-catalyzed coupling reaction of 2,x-dihalopyridines and phenols
General procedure: 2,4-Dibromopyridine (0.236 g, 1 mmol) and phenol (0.094 g, 1 mmol), CuI (19.0 mg, 0.1 mmol), TMEDA (11.6 mg, 0.1 mmol), and cesium carbonate (0.65 g, 2 mmol) were placed in DMSO (5 mL). The reaction was stirred at 110 °C under nitrogen atmosphere for 24 h. When the reaction mixture was cooled, the reaction mixture was filtered. The mixture was dissolved with dichloromethane (25 mL). Then the mixture was washed with brine (3×30 mL). The organic phase was dried over sodium sulfate. After evaporation of the solvent, the mixture was subjected to column chromatography with petroleum ether/ethyl acetate (20:1) as eluent to give pure product
References:
Zhou, Qizhong;Zhang, Bin;Du, Tieqi;Gu, Haining;Ye, Yuyuan;Jiang, Huajiang;Chen, Rener [Tetrahedron,2013,vol. 69,# 1,p. 327 - 333]
128071-98-7
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108-95-2
776 suppliers
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1353776-73-4
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58530-53-3
313 suppliers
$4.00/1g
108-95-2
776 suppliers
$14.00/25g
1353776-73-4
1 suppliers
inquiry
1352327-92-4
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