QUINOLINE-5-CARBOXYLIC ACID HYDRAZIDE synthesis
- Product Name:QUINOLINE-5-CARBOXYLIC ACID HYDRAZIDE
- CAS Number:96541-83-2
- Molecular formula:C10H9N3O
- Molecular Weight:187.2
7250-53-5
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Yield:96541-83-2 46%
Reaction Conditions:
Stage #1: quinoline-5-carboxylic acidwith 1,1′-carbonyldiimidazole in tetrahydrofuran at 20; for 2 h;
Stage #2: with hydrazine monohydrate in tetrahydrofuran;lithium hydroxide monohydrate at 20; for 2 h;
Steps:
A.1 Step 1 :
A solution of 5-quinolinecarboxylic acid (5.00 g, 28.87 mmol) and 1 ,1'- carbonyldiimidazole (5.20 g, 31.76 mmol) in tetrahydrofuran (40 mL ) was stirred at room temperature for 2 h. Then hydrazine hydrate (2.90 g, 57.74 mmol, 80% in water) was added to the above mixture. The reaction mixture was stirred at room temperature for 2 h. The solids were collected by filtration and dried over vacuum to afford quinoline-5- carbohydrazide (2.50 g, 46%) as a grey solid. MS m/z 188.1 [M+1]+.
References:
WO2022/20342,2022,A1 Location in patent:Page/Page column 40; 51
98421-25-1
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99-05-8
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