(R)-2-Amino-2-(4-fluorophenyl)ethanol synthesis
- Product Name:(R)-2-Amino-2-(4-fluorophenyl)ethanol
- CAS Number:174770-74-2
- Molecular formula:C8H10FNO
- Molecular Weight:155.17
93939-74-3
205 suppliers
$26.00/250mg
174770-74-2
57 suppliers
$68.00/100mg
Yield:174770-74-2 88%
Reaction Conditions:
Stage #1: (R)-2-(4-fluorophenyl)glycinewith lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 17 h;
Stage #2: with sodium hydroxide in tetrahydrofuran;water; for 0.166667 h;
Steps:
104
To a stirred solution of lithium aluminium hydride (1.0 M in THF, 11.9 ml, 11.9 mmol) at0 C was added 4- (R)-fluorophenylglycine (1.0 g, 5.9 mmol) portion wise over 1 hour. The mixture was stirred at room temperature for 16 hours. Water (0.45 ml), 4 NNaOH (0.45 ml) and water (1.34 ml) was added to the mixture and the mixture was stirred for 10 minutes before being filtered. The filtrate was concentrated to give a yellow residue. Flash chromatography(CombiFlash,CH2Cl2/MeOH/NH3 = 90/10/1) gave productas a white solid (800 mg,88%). 1H NMR 8 3.25 (m, 1 H), 3.30 (m, 1 H), 3.40 (m, 1 H), 3.83 (m, 1 H), 4.77 (br s, 1 H), 7.06 (m, 2 H), 7.37(m, 2 H).
References:
WO2005/49033,2005,A1 Location in patent:Page/Page column 114
439213-22-6
47 suppliers
$45.00/10mg
174770-74-2
57 suppliers
$68.00/100mg
19883-57-9
270 suppliers
$8.00/1g
174770-74-2
57 suppliers
$68.00/100mg
405-99-2
226 suppliers
$10.00/1g
174770-74-2
57 suppliers
$68.00/100mg
403-29-2
327 suppliers
$8.00/5g
174770-74-2
57 suppliers
$68.00/100mg