(R)-3-amino-N,N-dimethyl-4-(phenylthio)butanamide synthesis
- Product Name:(R)-3-amino-N,N-dimethyl-4-(phenylthio)butanamide
- CAS Number:870812-31-0
- Molecular formula:C12H18N2OS
- Molecular Weight:238.35
![N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester](/CAS2/GIF/870812-30-9.gif)
870812-30-9
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Yield:870812-31-0 96%
Reaction Conditions:
with hydrogen bromide;acetic acid at 20;
Steps:
1.1L (3R)-3-amino-N,N-dimethyl-4-(phenylsulfanyl)butanamide
(3R)-3-amino-N,N-dimethyl-4-(phenylsulfanyl)butanamide A suspension of EXAMPLE 1K (10.60 g, 28.46 mmol) in 50 mL 30% HBr/acetic acid was stirred at room temperature overnight. The resulting homogeneous reaction mixture was concentrated, diluted with water (200 mL) and 5% HCl (100 mL), and washed with diethyl ether (3*). The aqueous phase was adjusted to pH ~8-9 with solid Na2CO3 and extracted with dichloromethane (5*). The combined organic phases were dried (MgSO4), filtered, and concentrated to give the desired product (6.54 g, 96%). MS (CI) m/e 239 (M+H)+.
References:
US2005/272744,2005,A1 Location in patent:Page/Page column 12
![N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester](/CAS2/GIF/870812-29-6.gif)
870812-29-6
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