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ChemicalBook CAS DataBase List (R)-(+)-4-HYDROXY-2-PYRROLIDINONE

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

in ethanol

Steps:

R.2 Production of (R)-4-hydroxy-2-pyrrolidinone without adding a base catalyst
REFERENCE EXAMPLE 2 Production of (R)-4-hydroxy-2-pyrrolidinone without adding a base catalyst An ethanol solution (50 ml) of ethyl (R)-4-amino-3-hydroxybutyrate (4.4 g, 30 mmol) was subjected to reflux under heating for 12 hours. Ethanol was distilled off and the thus-obtained crude crystals were recrystallized from ethanol (14 ml) to obtain pale yellow crystals.

References:

Daicel Chemical Industries, Ltd. US6031113, 2000, A

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