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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
22348-32-9

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol synthesis

7synthesis methods
Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.
1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-

137496-68-5
2 suppliers
inquiry

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

22348-32-9
417 suppliers
$10.00/1g

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Yield:22348-32-9 100%

Reaction Conditions:

with sodium hydroxide in ethanol; for 2.5 h;Reflux;

References:

Nikolic, Nikola A.;Beak, Peter [Organic Syntheses,1997,vol. 74,p. 23 - 23]

100-59-4 Synthesis
PHENYLMAGNESIUM CHLORIDE

100-59-4
273 suppliers
$44.00/0.25mole

73323-65-6 Synthesis
BOC-D-PRO-OME

73323-65-6
180 suppliers
$10.00/5g

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

22348-32-9
417 suppliers
$10.00/1g

References
149-87-1 Synthesis
DL-Pyroglutamic acid

149-87-1
338 suppliers
$6.00/25g

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

22348-32-9
417 suppliers
$10.00/1g

References
2-Pyrrolidinone, 5-(hydroxydiphenylmethyl)-

21901-76-8
0 suppliers
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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

22348-32-9
417 suppliers
$10.00/1g

References
356790-44-8 Synthesis
(R)-(1-Benzylpyrrolidin-2-yl)diphenylMethanol

356790-44-8
27 suppliers
$35.00/100mg

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

22348-32-9
417 suppliers
$10.00/1g

References

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Related Search:

Pyrrolidine Biphenyl D(-)Prolinol (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-alpha,alpha-Diphenylmethylprolinol BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL (R)-A,A-BIS(3,5-DICHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE (R)-2-(Methoxydiphenylmethyl)pyrrolidine (R)-A,A-BIS(3-CHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE