(R,R)-Reboxetine synthesis
- Product Name:(R,R)-Reboxetine
- CAS Number:105017-38-7
- Molecular formula:C19H23NO3
- Molecular Weight:313.39
Yield:105017-38-7 84%
Reaction Conditions:
Stage #1: (2R,3R)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl esterwith 1H-imidazole;carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 2 h;
Stage #2: 2-Ethoxyphenolwith potassium tert-butylate in tetrahydrofuran;tert-butyl alcohol;Reflux;
Stage #3: with trifluoroacetic acid in dichloromethane at 20; for 6 h;
References:
Liu, Cheng;Lin, Zhi-Wei;Zhou, Zhao-Hui;Chen, Hong-Bin [Organic and Biomolecular Chemistry,2017,vol. 15,# 25,p. 5395 - 5401]
![Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, hydrochloride (1:1), (2R)-](/CAS/20211123/GIF/105017-40-1.gif)
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