Ritalinic acid synthesis
- Product Name:Ritalinic acid
- CAS Number:19395-41-6
- Molecular formula:C13H17NO2
- Molecular Weight:219.28
113-45-1
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19395-41-6
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Yield:19395-41-6 126 mg
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran;methanol at 20;
Steps:
1.1.1; 2.1.1; 3.1.1; 1.1.1; 2.1.1; 3.1.1 (1) Preparation of artificial hapten:
Weigh 200mg (0.914mmol) of Ritalin in a 100ml single-neck round bottom flask, add 8ml methanol to dissolve, then add 9ml tetrahydrofuran and 22ml 1N NaOH aqueous solution, add a stirrer, and stir at room temperature for 3 hours; Adjust pH=3 with hydrochloric acid, extract with 3×30 ml of ethyl acetate, combine the organic phases, dry the organic phases over anhydrous magnesium sulfate, filter, and concentrate to obtain 126 mg of white solid product A;The white solid product A was detected by TLC, and the chromatographic solution was 95% ethanol: 1,4-dioxane: dichloromethane: ammonia water = 8: 1: 10: 1 (v/v), product Rf= 0.2.
References:
CN114907255,2022,A Location in patent:Paragraph 0025; 0037; 0046; 0050; 0053; 0055; 0061; ...
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19395-41-6
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19395-41-6
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$24.73/1gm:
19395-41-6
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19395-41-6
233 suppliers
$16.80/1G