RO 41-0960 COMT IHIBITOR synthesis

5synthesis methods

preparation by demethylation of 2′-fluoro-4- hydroxy-3-methoxy-5-nitrobenzophenone with 48% hydrobromic acid in refluxing acetic acid for 4 h (86%).

Yield:125628-97-9 86.2%

Reaction Conditions:

with hydrogen bromide;acetic acid in acetic acid; for 4 h;Heating;

References:

Borgulya;Bruderer;Bernauer;Zurcher;Da Prada [Helvetica Chimica Acta,1989,vol. 72,# 5,p. 952 - 968]

1072-85-1 Synthesis

2426-87-1 Synthesis

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