RO 41-0960 COMT IHIBITOR
- CAS No.
- 125628-97-9
- Chemical Name:
- RO 41-0960 COMT IHIBITOR
- Synonyms
- or1139;Ro 41-0960 solid;Ro 410960,Ro 41 0960;RO 41-0960 COMT INHIBITOR;RO 41-0960 COMT IHIBITOR;(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone;(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanon;Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-;(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone , Ro 41-0960
- CBNumber:
- CB0504366
- Molecular Formula:
- C13H8FNO5
- Molecular Weight:
- 277.2
- MDL Number:
- MFCD00078597
- MOL File:
- 125628-97-9.mol
| Product description | Number | Pack Size | Price |
| Ro 41-0960 solid | R108 | 25mg | $173 |
| Ro 41-0960 solid | R108 | 100mg | $551 |
| Ro 41-0960 | 29621 | 5mg | $40 |
| Ro 41-0960 | 29621 | 10mg | $72 |
| Ro 41-0960 | 29621 | 25mg | $157 |
| Melting point | 169-171°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: <0.7 mg/mL, slightly soluble |
| form | solid |
| color | yellow |
| Water Solubility |
H2O: slightly soluble <0.7mg/mL 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0mg/mL ethanol: soluble |
| InChI | 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H |
| InChIKey | RQPAUNZYTYHKHA-UHFFFAOYSA-N |
| SMILES | Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F |
| FDA UNII | SXV6U29ZOI |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| RTECS | PC4952300 |
| Storage Class | 11 - Combustible Solids |
RO 41-0960 COMT IHIBITOR price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R108 | Ro 41-0960 solid | 125628-97-9 | 25mg | $173 | 2025-07-31 | Buy |
| Sigma-Aldrich | R108 | Ro 41-0960 solid | 125628-97-9 | 100mg | $551 | 2025-07-31 | Buy |
| Cayman Chemical | 29621 | Ro 41-0960 | 125628-97-9 | 5mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 29621 | Ro 41-0960 | 125628-97-9 | 10mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 29621 | Ro 41-0960 | 125628-97-9 | 25mg | $157 | 2024-03-01 | Buy |
RO 41-0960 COMT IHIBITOR Chemical Properties,Uses,Production
Uses
Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to tre at corpus striatum samples to test its effect on dopamine metabolism.
Preparation
preparation by demethylation of 2′-fluoro-4- hydroxy-3-methoxy-5-nitrobenzophenone with 48% hydrobromic acid in refluxing acetic acid for 4 h (86%).
Biological Activity
Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.
RO 41-0960 COMT IHIBITOR Preparation Products And Raw materials
RO 41-0960 COMT IHIBITOR Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 4933 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59936 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24964 | 58 |
| Tanmo Quality Inspection Technology Co., Ltd. | 4008-099-669 | 23419001name@qq.com | CHINA | 6043 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
View Lastest Price from RO 41-0960 COMT IHIBITOR manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-04 | Ro 41-0960
125628-97-9
|
US $258.00-142.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Ro 41-0960
125628-97-9
- US $258.00-142.00 / mg
- TargetMol Chemicals Inc.
