ChemicalBook CAS DataBase List Succinonitrile

Succinonitrile synthesis

13synthesis methods

Product Name:Succinonitrile
CAS Number:110-61-2
Molecular formula:C4H4N2
Molecular Weight:80.09

Succinonitrile is derived from the interaction of ethylene dibromide and potassium cyanide in the presence of alcohol.

542-76-7 Synthesis

542-76-7
135 suppliers
$32.00/25mL

75-86-5 Synthesis

75-86-5
2 suppliers
$64.90/5G

110-61-2
220 suppliers
$13.00/5g

Yield:110-61-2 98%

Reaction Conditions:

Stage #1: 2-hydroxy-2-methylpropanenitrilewith lithium hydroxide monohydrate in tetrahydrofuran at 50; for 1 h;
Stage #2: 3-Chloropropionitrile in tetrahydrofuran;

Steps:

10

General procedure: Dissolve 1.5 mol of acetone cyanohydrinIn a mixed solvent of 1,3-dimethylimidazolidinone and tetrahydrofuran (volume ratio 1:3), 1.5 mol of catalyst lithium hydroxide monohydrate was added, and after stirring at 50 ° C for one hour, 1 mol of benzyl bromide was added, TLC After the disappearance of the monitoring raw materials, the mixture was washed with water, extracted with ethyl acetate, and the ethyl acetate layer was washed with water and saturated brine, respectively.After drying over anhydrous Na 2 SO 4 , the mixture was filtered and concentrated to give phenylacetonitrile. The reaction time was 2.5 h, and the yield was 97%.

References:

CN110003047,2019,A Location in patent:Paragraph 0043-0049; 0051-0058