ChemicalBook CAS DataBase List Tak-715

Tak-715 synthesis

5synthesis methods

Product Name:Tak-715
CAS Number:303162-79-0
Molecular formula:C24H21N3OS
Molecular Weight:399.51

(4-METHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER

90101-20-5
72 suppliers
$60.00/100mg

303162-79-0
114 suppliers
$65.00/5mg

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 86 percent / Br₂; AcOH / 3 h / 80 °C
3.1: 60 percent / dimethylformamide / 14 h / 20 °C
4.1: Et₃N / tetrahydrofuran / 3 h / 20 °C
5.1: 59.8 g / HCl / tetrahydrofuran; H₂O / 14 h / 40 °C

References:

Miwatashi, Seiji;Arikawa, Yasuyoshi;Kotani, Etsuo;Miyamoto, Maki;Naruo, Ken-Ichi;Kimura, Hiroyuki;Tanaka, Toshimasa;Asahi, Satoru;Ohkawa, Shigenori [Journal of Medicinal Chemistry,2005,vol. 48,# 19,p. 5966 - 5979]