ChemicalBook CAS DataBase List N-(2-Hydroxyethyl)-2-pyrrolidone

N-(2-Hydroxyethyl)-2-pyrrolidone synthesis

10synthesis methods

Product Name:N-(2-Hydroxyethyl)-2-pyrrolidone
CAS Number:3445-11-2
Molecular formula:C6H11NO2
Molecular Weight:129.16

13865-19-5 Synthesis

13865-19-5
148 suppliers
$45.00/50mg

141-43-5 Synthesis

141-43-5
851 suppliers
$9.00/10g

3445-11-2
133 suppliers
$7.00/5g

Yield:-

Reaction Conditions:

in methanol

Steps:

7 EXAMPLE 7
EXAMPLE 7 A mixture of 1.1 g of methyl 4-oxobutyrate dissolved in 2 ml methanol, 4.05 g of 2-aminoethanol, and 0.2 g of 5% Ru/C was placed in a 70 ml glass-lined pressure reactor. The reactor was flushed and then pressurized with hydrogen to 1,000 psi, sealed and shaken in an air-oven at 100° C. for four hours. After cooling and venting of unreacted hydrogen, the mixture was filtered and analyzed by gas chromatography. The analysis disclosed complete conversion of methyl 4-oxobutyrate with formation of N-(beta-hydroxyethyl)-2-pyrrolidone as confirmed by gc-mass spectrometry.

References:

National Distillers and Chemical Corporation US4420620, 1983, A

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59776-88-4 Synthesis