Tenofovir synthesis
- Product Name:Tenofovir
- CAS Number:34956-22-4
- Molecular formula:C14H23O6PS
- Molecular Weight:350.37
Yield:34956-22-4 54%
Reaction Conditions:
with N,N-dimethyl-4-aminopyridine;triethylamine in dichloromethane at 20;Inert atmosphere;
Steps:
3 Example 3 Preparation of 4-methylbenzenesulfonic acid-1-methyl phosphate di-n-propyl ester
Di-n-propyl hydroxymethyl phosphate (2674 mg, 13.64 mmol) and p-toluenesulfonyl chloride (7776 mg, 40.3 mmol) were evacuated for 30 min under argon protection,Then 40 ml of ultra-dry dichloromethane was added, followed by triethylamine (1364 mg, 13.6 mmol)and 4-dimethylaminopyridine, stirred at room temperature overnight,Column purification to obtain di-n-propyl 4-methylbenzenesulfonic acid-1-methylphosphate(2.6g, yield 54%)
References:
CN115028661,2022,A Location in patent:Paragraph 0041-0044
1809-21-8
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