tert-butyl 2-(2-hydroxyethylthio)ethylcarbaMate synthesis
- Product Name:tert-butyl 2-(2-hydroxyethylthio)ethylcarbaMate
- CAS Number:75937-17-6
- Molecular formula:C9H19NO3S
- Molecular Weight:221.32
![2-[(2-AMINOETHYL)THIO]ETHAN-1-OL](/CAS/GIF/24304-84-5.gif)
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Yield:75937-17-6 100%
Reaction Conditions:
in dichloromethane at 20; for 0.5 h;
Steps:
1.a a ) tert-butyl-N-[2-( 2 -hydroxyethylsulfanyl )ethyl ] carbamate
In a 250 mL pear flask equipped with magnetic stirring, to a solution of B0C2O (2.12 g, 9.69 mmol) in 20 mL of DCM, was added a solution of 2-((2-aminoethyl)-thio)ethanol (1.17 g, 9.69 mmol) in 10 mL of DCM. The mixture was stirred at RT for 30 minutes. Solvent was evaporated under reduce pressure to give 2.21 g of tert-butyl-N-[2-(2- hydroxyethylsulfanyl)ethyl]carbamate as a colorless oil (yield=quantitative). (0351) LCMS-ESI: [M+H]+=122 (-Boc)
References:
WO2021/123116,2021,A1 Location in patent:Page/Page column 59-60
![TERT-BUTYL N-[2-(TOSYLOXY)ETHYL]CARBAMATE](/CAS/GIF/158690-56-3.gif)
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