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368426-87-3

tert-Butyl 3-cyano-4-fluorobenzylcarbamate synthesis

4synthesis methods
64113-84-4 Synthesis
2-Fluoro-5-methylbenzonitrile

64113-84-4
179 suppliers
$10.00/1g

tert-Butyl 3-cyano-4-fluorobenzylcarbamate

368426-87-3
10 suppliers
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 59 percent / NBS; AIBN / CCl4 / Heating
2: 100 percent / NaN3 / dimethylformamide / 20 °C
3: 85 percent / Ph3P; H20 / tetrahydrofuran / 0 - 20 °C
4: 83 percent / CH2Cl2

References:

Cui, Jingrong Jean;Araldi, Gian-Luca;Reiner, John E.;Reddy, Komandla Malla;Kemp, Scott J.;Ho, Jonathan Z.;Siev, Daniel V.;Mamedova, Lala;Gibson, Tony S.;Gaudette, John A.;Minami, Nathaniel K.;Anderson, Susanne M.;Bradbury, Annette E.;Nolan, Thomas G.;Semple [Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,# 20,p. 2925 - 2930]

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
864 suppliers
$13.50/25G

368426-86-2 Synthesis
5-(Aminomethyl)-2-fluorobenzonitrile

368426-86-2
57 suppliers
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tert-Butyl 3-cyano-4-fluorobenzylcarbamate

368426-87-3
10 suppliers
inquiry