tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate synthesis
- Product Name:tert-Butyl (4-broMopyridin-2-yl)(Methyl)carbaMate
- CAS Number:946000-13-1
- Molecular formula:C11H15BrN2O2
- Molecular Weight:287.15
207799-10-8
145 suppliers
$11.00/250mg
74-88-4
354 suppliers
$15.00/10g
946000-13-1
16 suppliers
$71.00/50mg
Yield:946000-13-1 76%
Reaction Conditions:
Stage #1: (4-bromopyridin-2-yl)-carbamic acid tert-butyl esterwith sodium hydride in tetrahydrofuran at 0; for 0.25 h;
Stage #2: methyl iodine in tetrahydrofuran at 0 - 20; for 16 h;
Steps:
tert-Butyl (4-bromo-pyridin-2-yl)-methyl-carbamate (160)To a solution of te/7-butyl carbamate 155 (300 mg, 1.10 mmol) in THF (5 mL) at 0°C is added sodium hydride (53 mg, 1.32 mmol, 60% dispersion in mineral oil) in one portion. After stirring 15 minutes, iodomethane is added (82 μL, 1.32 mmol) and the reaction mixture warmed to RT and stirred 16 h. The reaction is then quenched with 5% citric acid (10 mL) and extracted into EtOAc (2 x 10 mL). The EPO
References:
WO2008/57497,2008,A2 Location in patent:Page/Page column 296-297
18437-58-6
324 suppliers
$6.00/1g
946000-13-1
16 suppliers
$71.00/50mg
22282-99-1
396 suppliers
$6.00/5g
946000-13-1
16 suppliers
$71.00/50mg
5470-66-6
301 suppliers
$8.00/1g
946000-13-1
16 suppliers
$71.00/50mg
30766-03-1
266 suppliers
$7.00/1g
946000-13-1
16 suppliers
$71.00/50mg