tert-Butyl 4-carbamoylbenzylcarbamate synthesis
- Product Name:tert-Butyl 4-carbamoylbenzylcarbamate
- CAS Number:871721-44-7
- Molecular formula:C13H18N2O3
- Molecular Weight:250.29
24424-99-5
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Yield:871721-44-7 86%
Reaction Conditions:
in tetrahydrofuran at 20; for 2 h;
Steps:
14-9.1 Step 1 : Preparation of tert-butyl (4-carbamoylbenzvDcarbamate
4-(aminomethyl)benzamide (0.3 g) was dissolved in THF (5 ml) and Boc-anhydride (0.45 g) was added. The mixture was stirred at room temperature for 2 h and evaporated to dryness. The residue was purified by column silica gel chromatography to give tert-butyl (4-carbamoyl- benzyl)carbamate (0.43 g, 86%) which was used directly in the next step.
References:
WO2021/163631,2021,A1 Location in patent:Page/Page column 93
![4-[(tert-Butoxycarbonylamino)methyl]benzoic acid](/CAS/GIF/33233-67-9.gif)
33233-67-9
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56-91-7
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24424-99-5
816 suppliers
$13.50/25G
871721-44-7
19 suppliers
inquiry