TERT-BUTYL 4-CHLORO-3-HYDROXYPHENYLCARBAMATE synthesis
- Product Name:TERT-BUTYL 4-CHLORO-3-HYDROXYPHENYLCARBAMATE
- CAS Number:345893-27-8
- Molecular formula:C11H14ClNO3
- Molecular Weight:243.69
24424-99-5
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6358-06-1
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345893-27-8
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$188.50/500mg
Yield:345893-27-8 33 g (97%)
Reaction Conditions:
in tetrahydrofuran;
Steps:
1.c c).
c). 4-Chloro-3-hydroxyphenylcarbamic acid tert-butyl ester To a solution of 2-chloro-5-aminophenol (20 g, 0.14 mol) in THF (150 mL) was added a solution of di-tert-butyl dicarbonate (33 g, 0.15 mol) in THF (150 mL). The reaction was heated at reflux for 6 h, at which time it was allowed to cool to room temperature. The solvent was removed in vacuo and the residue diluted with ether (500 mL) and washed with 1 M citric acid (2*300 mL). The aqueous washings were extracted with ether (300 mL) and the combined organics washed with brine (300 mL), dried (MgSO4). and concentrated. The resultant brown solid was triturated with hexanes and dried in vacuo to give 33 g (97%) of the title compound: mp 103-106° C.
References:
US2003/100580,2003,A1
619-10-3
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345893-27-8
21 suppliers
$188.50/500mg