Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Tolfenamic acid

Tolfenamic acid synthesis

3synthesis methods
Tolfenamic acid is obtained by condensation of 2-chlorobenzoic acid with 3- chloro-2-methyl-phenylamine using CuBr2 in diethylenglycol dimethyl ether .
Synthesis_13710-19-5
-

Yield:13710-19-5 88.6%

Reaction Conditions:

Stage #1:ortho-chlorobenzoic acid with sodium hydroxide for 1 h;Reflux;
Stage #2:3-chloro-2-methylbenzenamine with aluminum oxide;sodium hydroxide for 3 h;Reflux;

Steps:

2 Example 2
100 g of o-chlorobenzoic acid and 25 g of sodium hydroxide were weighed into 500 mL of methyl isobutyl ketone and heated to refluxReaction 1 h.90 g of 3-chloro-2-methylaniline and 50 g of alumina-supported sodium hydroxide were weighed into a solution ofThe reaction mixture was heated and refluxed for 3 h, then cooled and added with 500 mL of water. The aqueous phase was acidified with concentrated hydrochloric acid until the pH was 2-3, and the mixture was stirred for lh to crystallize and filter. And the crude tosylate was recrystallized from ethanol / water mixed solvent to obtain 158.2 g of the refined product of Tofenamic Acid. The yield was 88.6%.

References:

Danyang Hengan Chemical Technology Research Institute Co., Ltd;Chen, Guoping;Xia, Fangfang;Du, chengming;Chen, Liqing;Wang, Xia;Zhang, Liang;Wang, Taoying;Jing, Jiren;Xia, Xinkai;Wang, Haida CN104557584, 2016, B Location in patent:Paragraph 0016; 0017; 0018

FullText

Tolfenamic acid Related Search: