trimebutine maleate synthesis
- Product Name:trimebutine maleate
- CAS Number:345659-09-8
- Molecular formula:C26H33NO9
- Molecular Weight:503.55
Yield:345659-09-8 91 %
Reaction Conditions:
in isopropyl alcohol;Reflux;Large scale;Temperature;Solvent;
Steps:
1.5-2.5; 4 (5) Salt-forming reaction:
Add isopropanol 15L, trimebutine 5kg and maleic acid 1.5kg (relative to 1g of trimebutine, the dosage of maleic acid is 0.3g, and the dosage of isopropanol is 3ml), then stirred at 40°C for 3.5h.After finishing, add gac 100g in material, be warming up to reflux, material dissolves clarification, then filters gac.After the filtrate was cooled to 10°C at a rate of 2°C/min, it was crystallized and filtered. After washing the obtained filter cake with 2L of isopropanol, it was dried at 50°C for 7 hours to obtain 5.6kg of trimebutine maleate with a purity of is 99.9%, and the yield of the salt-forming reaction is 91%.
References:
CN115385806,2022,A Location in patent:Paragraph 0069; 0079-0081; 0091-0092; 0095-0096
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