Urea, 1-methylcyclopropyl- synthesis
- Product Name:Urea, 1-methylcyclopropyl-
- CAS Number:58102-14-0
- Molecular formula:C5H10N2O
- Molecular Weight:114.15
1118-02-1
138 suppliers
$77.00/5g
88887-87-0
149 suppliers
$65.00/100mg
58102-14-0
2 suppliers
inquiry
Yield:58102-14-0 66%
Reaction Conditions:
with triethylamine in dichloromethane at 20;
Steps:
71 Compound 71.1. 1-(1-methylcyclopropyl)urea
To a stirred solution of 1- methylcyclopropan-1 -amine hydrochloride salt (429 mg, 3.99 mmol, 1.00 equiv) and triethylamine (268 mg, 2.65 mmol, 1.00 equiv) in CH2CI2 (6 mL) was added trimethylsilyl isocyanate (366 mg, 3.18 mmol, 1.20 equiv). The resulting mixture was stirred at room temperature overnight and was quenched by the dropwise addition of CH3OH (2 mL) at 0 °C. The resulting solution warmed to room temperature and stirred for an additional 1 h. The resulting mixture was concentrated under reduced pressure. The crude product was precipitated from ΟΗ:Ε20 (1 :40) affording 300 mg (66%) of the title compound as a white solid.
References:
WO2014/205223,2014,A1 Location in patent:Paragraph 0193-0194
6914-76-7
269 suppliers
$10.00/250mg
58102-14-0
2 suppliers
inquiry