| Identification | More | [Name]
tert-Butyl chloroacetate | [CAS]
107-59-5 | [Synonyms]
CHLOROACETIC ACID T-BUTYL ESTER
CHLOROACETIC ACID TERT-BUTYL ESTER
reft-Butyl chloroacetate
T-BUTYL CHLOROACETATE
TERT-BUTYL CHLORACETATE
TERT-BUTYL CHLOROACETATE
Acetic acid, chloro-, tert-butyl ester
aceticacid,chloro-,1,1-dimethylethylester
ClCH2C(O)OC(CH3)3
#ntert.-Butyl chloroacetate
1,4-Dimethyl-5H-pyrido[4,3-β]indol-3-amine-13C,15N Monoacetate
3-Amino-1,4-dimethyl-5h-pyrido[4,3-β]indole-13C2,15N Acetate
tert-Butyl chloroacetate, 98+%
1,1-Dimethylethyl chloroacetate
Chloroacetic acid 1,1-dimethylethyl ester
Chloroacetic acid 1,1-dimethylethyl | [EINECS(EC#)]
203-506-1 | [Molecular Formula]
C6H11ClO2 | [MDL Number]
MFCD00000930 | [Molecular Weight]
150.6 | [MOL File]
107-59-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C,N,Xn,Xi,F | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R10:Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S60:This material and/or its container must be disposed of as hazardous waste .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 2920 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
AF8985500
| [F ]
19-21 | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29154000 | [Safety Profile]
A poison by ingestion.
Moderately toxic by inhalation skin contact.
S severe sluin and moderate eye irritant.
When heated to decomposition it emits
toxic vapors of Cl-. |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion. Moderately toxic by
inhalation skin contact. Severe skin and moderate
eye irritant.
| [Chemical Properties]
clear colorless to yellow liquid | [Uses]
In the glycidic ester condensation. | [Preparation]
tert-Butyl chloroacetate synthesis: The tert-butanol was added to the mixture of chloroacetyl chloride and N,N-dimethylaniline, and the temperature was kept below 30°C. The reactant was poured into water, washed and dried, and then fractionated under reduced pressure. The fractions at 48-49°C (1.46kPa) were collected to obtain tert-butyl chloroacetate with a yield of 63%. | [Purification Methods]
Check the NMR spectrum; if satisfactory then distil in a vacuum; if not then dissolve in Et2O, wash with H2O, 10% H2SO4 until the acid extract does not become cloudy when made alkaline with NaOH. Wash the organic layer again with H2O, then saturated aqueous NaHCO3, dry over Na2SO4, evaporate and fractionate it through a carborundum-packed column or a 6-inch Widmer column (p 11, see tert-butyl ethyl malonate for precautions to avoid decomposition during disillation). [Johnson et al. J Am Chem Soc 75 4995 1953, Baker Org Synth Coll Vol III 144 1944, Beilstein 2 III 444.] |
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