| Identification | More | [Name]
5-METHOXY-2-METHYLINDOLE | [CAS]
1076-74-0 | [Synonyms]
5-METHOXY-2-METHYLINDOLE
AKOS JY2082626
5-Methoxy-2-methylindole, 99+%
5-Methoxy-2-methyindole | [EINECS(EC#)]
214-066-5 | [Molecular Formula]
C10H11NO | [MDL Number]
MFCD00005620 | [Molecular Weight]
161.2 | [MOL File]
1076-74-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light beige crystalline powder or | [Melting point ]
86-88 °C (lit.) | [Boiling point ]
145 °C / 1.5mmHg | [density ]
1.0840 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
0-6°C | [solubility ]
Soluble in methanol (very faint turbidity.) | [form ]
Crystalline Powder or Crystals | [pka]
17.28±0.30(Predicted) | [color ]
White to light beige | [Detection Methods]
HPLC,NMR | [InChIKey]
VSWGLJOQFUMFOQ-UHFFFAOYSA-N | [CAS DataBase Reference]
1076-74-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Questions and Answers (Q&A) | Back Directory | [Description]
5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. It is also employed in inhibiting the chlorinating activity of myeloperoxidase (MPO) and in the metabolic synthesis of acrylacetic acid anti-inflammatory synthesis.
| [References]
https://www.alfa.com/en/catalog/B21348/
http://www.sigmaaldrich.com/catalog/product/aldrich/m15451?lang=en®ion=US
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methoxy-2-methylindole#section=2D-Structure
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| Hazard Information | Back Directory | [Chemical Properties]
white to light beige crystalline powder or | [Uses]
An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis. | [Uses]
It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis. | [Uses]
reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation5 | [Definition]
ChEBI: 5-Methoxy-2-methyl-1H-indole is a member of indoles. |
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