| Identification | More | [Name]
Cilnidipine | [CAS]
132203-70-4 | [Synonyms]
1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER
ATELEC
CILNIDIPINE
CINALONG
(+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
FRC-8653
SISCARD
(e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste
5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m
Cinildipine
CINILDPINE
Cinidipine
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard,
CILNIDPINE
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
clinidipine
FRG 8653
Cilnidipine and intermediates | [EINECS(EC#)]
634-350-6 | [Molecular Formula]
C27H28N2O7 | [MDL Number]
MFCD00865853 | [Molecular Weight]
492.52 | [MOL File]
132203-70-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
97-99°C | [Boiling point ]
652.6±55.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
H2O: ≤2mg/mL | [form ]
powder | [pka]
2.61±0.70(Predicted) | [color ]
light yellow | [Usage]
A dihydropyridine calcium channel blocker | [Merck ]
14,2275 | [InChIKey]
KJEBULYHNRNJTE-DHZHZOJOSA-N | [CAS DataBase Reference]
132203-70-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
41 | [Safety Statements ]
26-39 | [WGK Germany ]
3 | [RTECS ]
US7975550 | [HS Code ]
29333990 | [Toxicity]
LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada) |
| Questions And Answer | Back Directory | [Description]
Clinidipine is a kind of calcium channel blocker. It is a kind of novel calcium antagonist with the blocking effect on both L-type and N-type calcium channels. It is mainly used for the treatment of hypertension. Based on its effect on both N-type and L-type calcium channel, it can dilate both arterioles and venules, further reducing the pressure in the capillary bed. In addition, cilinidipine can attenuate the platelet activation associated with catecholamines.
| [References]
https://www.drugbank.ca/drugs/DB09232
https://en.wikipedia.org/wiki/Cilnidipine
|
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Originator]
Fujirebio (Japan) | [Uses]
A dihydropyridine calcium channel blocker | [Uses]
A dihydropyridine calcium channel blocker. | [Uses]
antihypertensive;dihydropyridine calcium channel blocker | [Definition]
ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive. | [Brand name]
Cinalong;Siscard;Atelec | [Biological Activity]
Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia. | [Biochem/physiol Actions]
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC. | [storage]
4°C, protect from light |
|
|