- Methyl 3-aminocrotonate
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- $0.00 / 25KG
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2023-09-04
- CAS:14205-39-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | Methyl 3-aminocrotonate Basic information |
| | Methyl 3-aminocrotonate Chemical Properties |
| Melting point | 81-83 °C(lit.) | | Boiling point | 112°C 42mm | | density | 1.1808 (rough estimate) | | vapor pressure | 2.79-2.853hPa at 25℃ | | refractive index | 1.4538 (estimate) | | Fp | 91 °C | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | 18g/l | | pka | 5.27±0.70(Predicted) | | form | Crystalline Powder | | color | White to slightly yellow | | PH | 8-9 (18g/l, H2O, 20℃) | | Water Solubility | insoluble | | Sensitive | Hygroscopic | | BRN | 956592 | | InChIKey | XKORCTIIRYKLLG-ONEGZZNKSA-N | | LogP | -0.27 at 25℃ | | CAS DataBase Reference | 14205-39-1(CAS DataBase Reference) | | EPA Substance Registry System | 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1) |
| | Methyl 3-aminocrotonate Usage And Synthesis |
| Chemical Properties | Crystals, yellowish-white | | Uses | Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity. | | Uses | Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet | | Uses | Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified. | | Preparation | 3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists. | | General Description | Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin. | | Flammability and Explosibility | Not classified |
| | Methyl 3-aminocrotonate Preparation Products And Raw materials |
| Preparation Products | Manidipine-->Amlodipine-->Nitrendipine-->Felodipine-->Benidipine-->Isradipine-->Nisoldipine-->Cilnidipine-->Phthaloyl amlodipine-->Lercanidipine hydrochloride-->2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL--->Methyl 6-chloro-2-Methylnicotinate-->4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid-->Felodipine 3,5-DiMethyl Ester-->3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide |
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