| Identification | More | [Name]
1,3-Difluorobenzene | [CAS]
372-18-9 | [Synonyms]
1,3-DIFLUOROBENZENE
M-DIFLUOROBENZENE
1,3-difluroethylene
Benzene, m-difluoro-
benzene,1,3-difluoro-
Benzene,m-difluoro-
Difluoro-1,3-benzene
m-difluoro-benzen
meta-Difluorobenzene
1?-Difluorobenzene
m-Difluro Benzene
1,3-DIFLUOROBENZEN
1,3-DIFLUOROBENZENE, 99+%
1,3-DifluorobenzeneExtraPure
DIFLOUROBENZENE
1,3-Difluorbenzol
3-DifluoroBenzene
1,3-DIFLUOROBENZENEFLOCONAZOLE
1,3 DIFLOUROBENZENE extrapure | [EINECS(EC#)]
206-746-5 | [Molecular Formula]
C6H4F2 | [MDL Number]
MFCD00000327 | [Molecular Weight]
114.09 | [MOL File]
372-18-9.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLORLESS TO YELLOWISH LIQUID | [Melting point ]
-59 °C
| [Boiling point ]
83 °C | [density ]
1.163 g/mL at 25 °C(lit.)
| [vapor pressure ]
11.034-19.924kPa at 20-38.2℃ | [refractive index ]
n20/D 1.438(lit.)
| [Fp ]
36 °F
| [storage temp. ]
Flammables area | [solubility ]
1.1g/l | [form ]
Liquid | [color ]
Clear colorless to yellow | [Specific Gravity]
1.163 | [Water Solubility ]
insoluble | [BRN ]
1904537 | [Dielectric constant]
5.2400000000000002 | [LogP]
2.21-2.52 at 25℃ and pH6.5 | [CAS DataBase Reference]
372-18-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1,3-difluoro-(372-18-9) |
| Questions And Answer | Back Directory | [Synthesis]
Higher yields were observed when CsF and HF were reacted with 1,3-dichlorobenzene,
which gave I ,3-difluorobenzene.
 | [Chemical Properties]
1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yellowish liquid. Its melting point is -59 °C, boiling point is 83 °C and flash point is 2 oC. It is insoluble in water and stable under normal temperatures and pressures. It is toxic and flammable. It will produce toxic fluoride gas by heat.
| [Uses]
1,3-Difluorobenzene has been extensively used in the synthesis of pharmaceutical and pesticide intermediate. For example, it can be used for the synthesis of fluorinated medicine such as Fluconazole, etc. and pesticide (Flucycloxuron, Diflubenzuro, etc.). It can also be used to synthesize liquid crystal materials.
|
| Safety Data | Back Directory | [Hazard Codes ]
F,Xn | [Risk Statements ]
R11:Highly Flammable.
R20:Harmful by inhalation. | [Safety Statements ]
S7:Keep container tightly closed .
S16:Keep away from sources of ignition-No smoking .
S29:Do not empty into drains .
S33:Take precautionary measures against static discharges .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 1993 3/PG 2
| [WGK Germany ]
1
| [RTECS ]
CZ5652000
| [Hazard Note ]
Highly Flammable | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29036990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrochloric acid-->Sodium nitrite-->Fluoroboric acid-->m-Phenylenediamine-->3-Nitroaniline-->Benzene, 1,3-difluoro-2-(triMethylsilyl)--->2,6-Difluoronitrobenzene-->2,4-Difluorophenylboronic acid-->2,4-Difluorobenzotrifluoride | [Preparation Products]
Fluconazole-->6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole-->2,6-Difluorophenol-->Risperidone-->1-Bromo-2,4-difluorobenzene-->2,4-Difluoronitrobenzene-->3,5-Difluorobenzoic acid-->3-(2',4'-DIFLUOROPHENYL)-3-OXOPROPANENITRILE-->2,4-Difluorophenylacetic acid-->6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride-->2',4'-Difluoroacetophenone-->3-FLUOROBENZYLOXYBENZENE-->1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]- |
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