| Identification | More | [Name]
5-Nitro-1,10-phenanthroline | [CAS]
4199-88-6 | [Synonyms]
5-NITRO-1,10-PHENANTHROLINE
NITROFERROIN
TIMTEC-BB SBB008850
5-nitro-10-phenanthroline
5-NITRO-1 10-PHENANTHROLINE HYDRATE &
5-Nitro-1,10-phenanthroline,98%
1,10-Phenanthroline, 5-nitro- | [EINECS(EC#)]
224-097-6 | [Molecular Formula]
C12H7N3O2 | [MDL Number]
MFCD00004981 | [Molecular Weight]
225.2 | [MOL File]
4199-88-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow to yellow-brown crystalline powder | [Melting point ]
202-204 °C(lit.)
| [Boiling point ]
366.71°C (rough estimate) | [density ]
1.2844 (rough estimate) | [refractive index ]
1.5700 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
crystalline
| [pka]
pK1:3.232(+1) (25°C) | [color ]
yellow to orange
| [Water Solubility ]
insoluble | [Detection Methods]
HPLC,NMR,MS | [BRN ]
196245 | [CAS DataBase Reference]
4199-88-6(CAS DataBase Reference) | [EPA Substance Registry System]
4199-88-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow to yellow-brown crystalline powder | [Uses]
5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline. | [Biochem/physiol Actions]
Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity. | [Purification Methods]
Crystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.] |
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