| Identification | More | [Name]
Mandelonitrile | [CAS]
532-28-5 | [Synonyms]
ALPHA-CYANOBENZYL ALCOHOL
ALPHA-HYDROXYPHENYLACETONITRILE
BENZALDEHYDE CYANOHYDRIN
DL-ALPHA-HYDROXYPHENYLACETONITRILE
DL-MANDELIC ACID NITRILE
MANDELIC ACID NITRILE
MANDELONITRILE
Acetonitrile, hydroxyphenyl-
alpha-hydroxy-benzeneacetonitril
alpha-Hydroxybenzeneacetonitrile
Amygdalonitrile
Benzaldehydecaanohydrin
Benzaldehydkyanhydrin
-Cyanobenzylalcohol
Glycolonitrile, phenyl-
-Hydroxybenzeneacetonitrile
hydroxyphenyl-acetonitril
Hydroxyphenylacetonitrile
Nitril kyseliny mandlove
nitrilkyselinymandlove | [EINECS(EC#)]
208-532-7 | [Molecular Formula]
C8H7NO | [MDL Number]
MFCD00004487 | [Molecular Weight]
133.15 | [MOL File]
532-28-5.mol |
| Chemical Properties | Back Directory | [Appearance]
reddish-brown liquid | [Melting point ]
-10 °C | [Boiling point ]
170 °C(lit.) | [density ]
1.117 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.530(lit.)
| [Fp ]
207 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
alcohol: freely soluble | [form ]
Liquid | [pka]
10.50±0.20(Predicted) | [color ]
Yellow to brown | [Stability:]
Stable, but moisture sensitive. Combustible. Incompatible with strong oxidizing agents. | [Sensitive ]
Moisture Sensitive | [Merck ]
14,5719 | [BRN ]
2207122 | [Dielectric constant]
17.0（23℃） | [LogP]
0.830 (est) | [CAS DataBase Reference]
532-28-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzeneacetonitrile, «alpha»-hydroxy-(532-28-5) | [EPA Substance Registry System]
532-28-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 3276 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
OO8400000
| [F ]
21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29269090 | [Safety Profile]
Poison by intravenous
and subcutaneous routes. Mutation data
reported. A severe eye irritant. When heated
to decomposition it emits toxic fumes of
NOx and CN-. See also NITRILES. | [Toxicity]
LD50 orally in Rabbit: 116 mg/kg |
| Hazard Information | Back Directory | [General Description]
Reddish-brown to dark red-brown liquid. | [Reactivity Profile]
Nitriles, such as ALPHA-HYDROXYBENZENEACETONITRILE(532-28-5), may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. | [Air & Water Reactions]
This compound is sensitive to moisture. . Insoluble in water. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
This chemical is combustible. | [Chemical Properties]
reddish-brown liquid | [Occurrence]
Mandelonitrile, is a yellow, oily liquid, insoluble in water, but soluble in alcohol and diethyl ether. Mandelonitrile is a component of the glycoside amygdalin, a precursor of laetrile found in the leaves and seeds on most Prunus species (plum, peach, apricot, etc). In 1832, mandelonitrile was the first cyanohydrin to be synthesized. It is commercially prepared from benzaldehyde and hydrogen cyanide. Mandelonitrile is used by certain insects (tiger beetles, an African millipede) as a defense fluid. After expelling the fluid an enzyme catalyzes the conversion of mandelonitrile to benzaldehyde and HCN, which is usually fatal to the insect’s enemy. | [Uses]
Mandelonitrile has been used to extract mandeloamide by the nitrilase variants. | [Definition]
ChEBI: A cyanohydrin that is phenylacetonitrile in which one of the methylene hydrogens is replaced by a hydroxy group. | [Toxicology]
Mandelonitrile is rather toxic with an LD50 value (rat, oral) of 116 mg/kg. This high toxicity may be due to the equilibrium of the cyanohydrin with benzaldehyde and hydrogen cyanide. |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|