| Identification | More | [Name]
2-Hexanone | [CAS]
591-78-6 | [Synonyms]
2-HEXANONE
BUTYL METHYL KETONE
MBK
Methyl buthyl ketone
METHYL BUTYL KETONE
METHYL N-BUTYL KETONE
MNBK
N-BUTYL METHYL KETONE
2-Hexanon
2-Ketohexane
2-Oxohexane
Hexan-2-on
Hexan-2-one
Hexanone-2
Ketone, butyl methyl
ketone,butylmethyl
Methyl-n-butylketon
methyln-butylketone(mbk)
n-C4H9COCH3
propylacetone | [EINECS(EC#)]
209-731-1 | [Molecular Formula]
C6H12O | [MDL Number]
MFCD00009482 | [Molecular Weight]
100.16 | [MOL File]
591-78-6.mol |
| Chemical Properties | Back Directory | [Appearance]
MNBK is a colorless liquid with an acetonelike odor. The odor threshold is 0.08 ppm. | [Melting point ]
-57 °C | [Boiling point ]
127 °C(lit.) | [density ]
0.812 g/mL at 25 °C(lit.)
| [vapor pressure ]
10 mm Hg ( 39 °C)
| [refractive index ]
n20/D 1.401(lit.)
| [Fp ]
95 °F
| [storage temp. ]
2-8°C | [solubility ]
Soluble in acetone, ethanol, and ether (Weast, 1986) | [form ]
Liquid | [pka]
-8.30 (quoted, Riddick et al., 1986) | [color ]
Clear colorless to light yellow | [Odor]
at 1.00 % in dipropylene glycol. fruity fungal meaty buttery | [Stability:]
Stable. Flammable. Incompatible with oxidizing agents, strong bases, reducing agents. | [Odor Threshold]
0.024ppm | [Odor Type]
fruity | [Water Solubility ]
2 g/100 mL (20 ºC) | [Merck ]
14,6033 | [BRN ]
1737676 | [Henry's Law Constant]
24.4 at 37 °C (static headspace-GC, Bylaite et al., 2004) | [Dielectric constant]
14.6（15℃） | [Exposure limits]
NIOSH REL: TWA 1 ppm (4 mg/m3), IDLH 1,600 ppm; OSHA PEL: TWA
100 ppm (410 mg/m3); ACGIH TLV: TWA 5 ppm, STEL 10 ppm (adopted). | [InChIKey]
QQZOPKMRPOGIEB-UHFFFAOYSA-N | [LogP]
1.380 | [CAS DataBase Reference]
591-78-6(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Hexanone(591-78-6) | [EPA Substance Registry System]
591-78-6(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
2-Hexanone is a colorless to pale yellow liquid with a sharp odor. It dissolves very easily in
water and is miscible in ethanol, methanol, and benzene. 2-Hexanone evaporates easily into
the air as a vapor. It is stable, flammable, and incompatible with oxidizing agents, strong bases,
and reducing agents. 2-Hexanone is a waste product of wood pulping, coal gasifi cation, and
oil shale operations. Formerly, 2-hexanone was in use as a paint and paint thinner with other
chemical substances, and to dissolve oils and waxes.and is used as a solvent and organic syn-
thesis intermediates. However, the industrial uses of 2-hexanone is now very much restricted. | [General Description]
A clear colorless liquid. Flash point 95°F. Less dense than water. Vapors heavier than air. | [Reactivity Profile]
METHYL BUTYL KETONE(591-78-6) is incompatible with oxidizing agents. METHYL BUTYL KETONE(591-78-6) may also react with strong bases and reducing agents. | [Air & Water Reactions]
Highly flammable. Slightly soluble in water. | [Hazard]
Flammable, moderate fire risk, explosive limits 1.2–8% in air. Irritant to eyes and
mucous membranes, narcotic in high concentration,
absorbed by skin. Causes peripheral neuropathy and
testicular damage. | [Health Hazard]
Inhalation of high concentrations of vapor may result in narcosis; peripheral neuropathy may develop. Ingestion of large amounts may cause some systemic injury. Contact with eyes causes mild to moderate irritation. Liquid irritates skin; prolonged or repeated contact may cause defatting of the skin with resultant dermatitis. | [Potential Exposure]
The material is used as a solvent | [Fire Hazard]
This chemical is flammable. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit | [Shipping]
UN1224 Ketones, liquid, n.o.s., Hazard Class: 3;
Labels: 3-Flammable liquid, Technical Name Required | [Description]
2-Hexanone has been used as a solvent for both cellulose- and
resin-based coating systems. In the early 1970s, a number of
workers in the print department of a coated fabrics plant
developed severe peripheral neuropathy from an unknown
cause. In search of an etiological agent, and in the absence of
other neurotoxicants, 2-hexanone was implicated as it was
recently substituted for methyl isobutyl ketone in the
manufacturing process. Similar observations in workers
exposed to 2-hexanone may have resulted in the decline in
production and use in the United States. | [Waste Disposal]
Dissolve or mix the
material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber.
All federal, state, and local environmental regulations
must be observed. | [Physical properties]
Clear, colorless to pale yellow, flammable liquid with an odor resembling acetone and 2-butanone.
Nagata and Takeuchi (1990) reported an odor threshold concentration of 24 ppbv. Amoore and
Hautala (1983) reported odor threshold concentrations of 250 μg/L and 76 ppbv in water and air,
respectively. | [Uses]
2-Hexanone is used in various organic chemical syntheses. It is used in the synthesis of (+/-)-monomorine. It is also used in the preparation of alcohols by transfer hydrogenation of ketones. | [Uses]
As industrial solvents for adhesives,
lacquers, paint removers, and acrylic coatings | [Uses]
Methyl butyl ketone (MBK) is used as asolvent for nitrocellulose, resins, lacquers,oils, fats, and waxes. | [Definition]
ChEBI: 2-Oxohexane is a ketone. | [Production Methods]
MnBK can be produced by a reaction between acetic acid and ethylene under pressure MnBK can be produced by a reaction between acetic acid and ethylene under pressure. | [Synthesis Reference(s)]
Tetrahedron Letters, 24, p. 5181, 1983 DOI: 10.1016/S0040-4039(00)88391-4
Journal of the American Chemical Society, 89, p. 5708, 1967 DOI: 10.1021/ja00998a040 | [Environmental Fate]
Biological. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM
BOD/mM 2-hexanone) and ThOD were 5.22 and 61.4%, respectively (Vaishnav et al., 1987).
Photolytic. A second-order photooxidation rate constant of 8.97 x 10-12 cm3/molecule?sec for the
reaction of 2-hexanone and OH radicals in the atmosphere at 299 K was reported by Atkinson
(1985).
Chemical/Physical. 2-Hexanone will not hydrolyze because it has no hydrolyzable functional
group (Kollig, 1995). | [Toxicity evaluation]
Regardless of the route of exposure, both human and animal
studies indicate that the nervous system is the target organ of
2-hexanone toxicity with its metabolite, 2,5-hexanedione,
serving as the neurotoxic agent. 2,5-Hexanedione binds covalently
to axonal components of the nerve tissue. In vitro studies
have shown that this metabolite reacts with the nucleophilic
lysine 3-amino groups to ultimately form 2,5-dimethylpyrrole
adducts with neurofilaments. Neurofilament aggregates concentrate
in the distal subterminal axon, resulting in axonal
swelling, or distal axonopathy, just proximal to the nodes of
Ranvier. These reactions may lead to the manifestation of
peripheral neuropathy. | [Incompatibilities]
Violent reaction with oxidizers. May form unstable peroxides. Attacks plastics. |
| Safety Data | Back Directory | [Hazard Codes ]
T,F | [Risk Statements ]
R10:Flammable.
R48/23:Toxic: danger of serious damage to health by prolonged exposure through inhalation .
R62:Possible risk of impaired fertility.
R67:Vapors may cause drowsiness and dizziness.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 1224 3/PG 3
| [WGK Germany ]
1
| [RTECS ]
MP1400000
| [Autoignition Temperature]
530 °C | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29141900 | [storage]
2-Hexanone should be kept stored in a tightly closed container, in a cool, dry place, away
from sources of ignition. | [Precautions]
Occupational workers should be careful when using and handling 2-hexanone. Workers
should wash thoroughly after handling the chemical substance. Workers should avoid contact of 2-hexanone with the eyes, skin, and clothing and also avoid contact with heat,
sparks, and flame. | [Hazardous Substances Data]
591-78-6(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 2.59 g/kg (Smyth) | [IDLA]
1,600 ppm |
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