酪氨酸磷酸化抑制剂AG1295
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- CAS号:
- 71897-07-9
- 英文名:
- AG 1295
- 英文别名:
- AG 1295;NSC 380341;AG 1295 USP/EP/BP;TYRPHOSTIN AG 1295;TYROPHOSTIN AG1295;AG-1295
(NSC 380341;TYRPHOSTIN AG 1295, 99+%;AG 1295 PLATELET-DERIVED GROW;6,7-DIMETHYL-2-PHENYLQUINOXALINE;Quinoxaline, 6,7-dimethyl-2-phenyl-
- 中文名:
- 酪氨酸磷酸化抑制剂AG1295
- 中文别名:
- 6,7-二甲基-2-苯基喹噁啉;6,7-二甲基-2-苯基喹喔啉;酪氨酸磷酸化抑制剂AG1295
- CBNumber:
- CB5683675
- 分子式:
- C16H14N2
- 分子量:
- 234.3
- MOL File:
- 71897-07-9.mol
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酪氨酸磷酸化抑制剂AG1295化学性质
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熔点:
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121 °C
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沸点:
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398.3±37.0 °C(Predicted)
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密度:
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1.127±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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Chloroform (Slightly), Ethyl Acetate (Slightly)
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形态:
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White solid
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酸度系数(pKa):
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1.29±0.30(Predicted)
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颜色:
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Yellow
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酪氨酸磷酸化抑制剂AG1295性质、用途与生产工艺
AG 1295 是一种选择性血小板衍生生长因子受体 (PDGFR) 酪氨酸激酶抑制剂。AG1295 能抑制 PDGFR 的自磷酸化，对 EGF 受体的自磷酸化无效。
AG 1295 inhibits PDGFR autophosphorylation with IC
50
s of 0.3-0.5 μM and 0.5-1 μM for membrane autophosphorylation assays and Swiss 3T3 cells, respectively.
AG1295 (10 μM, 100 μM) significantly inhibits rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB in vitro.
Cell Viability Assay
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Cell Line:
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Rabbit conjunctival fibroblasts cells
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Concentration:
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1 μM, 10 μM, 100 μM
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Incubation Time:
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3 days
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Result:
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Inhibited rabbit conjunctival fibroblast cell growth stimulated by PDGF-AA or PDGF-BB.
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AG-1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation.
AG1295 (12 mg/kg; i.p.; daily; for 14 or 21 days) significantly reduces interstitial fibrosis as verified by a smaller Sirius-Red stained area and also by a reduced number of macrophages, and by the ED-A+ fibronectin deposition and the number of cells positive for alpha-smooth muscle actin.
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Animal Model:
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Sprague-Dawley rats (240-270 g)
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Dosage:
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12 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 14 or 21 days
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Result:
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Attenuated interstitial fibrosis in rat kidney after unilateral obstruction.
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酪氨酸磷酸化抑制剂AG1295
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101957 | 酪氨酸磷酸化抑制剂AG1295
AG 1295 | 71897-07-9 | 5mg | 600元 |
| 2024/04/30 | HY-101957 | 酪氨酸磷酸化抑制剂AG1295
AG 1295 | 71897-07-9 | 10mM * 1mLin DMSO | 660元 |
71897-07-9, 酪氨酸磷酸化抑制剂AG1295 相关搜索:
- Platelet Derived Growth Factor Receptor (PDGFR)
- Receptor Tyrosine Kinase Inhibitors
- Kinase/Phosphatase Biology
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- 70897-07-9
- 6,7-二甲基-2-苯基喹噁啉
- 6,7-二甲基-2-苯基喹喔啉
- 酪氨酸磷酸化抑制剂AG1295
- 71897-07-9
- Platelet-derived growth factor receptor,RTK,AG 1295,inhibit,PDGF-receptor,AG-1295,autophosphorylation,Inhibitor,AG1295,PDGFR
- AG 1295 USP/EP/BP
- NSC 380341
- AG-1295
(NSC 380341
- Quinoxaline, 6,7-dimethyl-2-phenyl-
- TYRPHOSTIN AG 1295, 99+%
- AG 1295 PLATELET-DERIVED GROW
- TYRPHOSTIN AG 1295
- TYROPHOSTIN AG1295
- AG 1295
- 6,7-DIMETHYL-2-PHENYLQUINOXALINE