OPC 3689 西洛酰胺
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- CAS号:
- 68550-75-4
- 英文名:
- CILOSTAMIDE
- 英文别名:
- OCP 3689;OPC 3689;CILOSTAMIDE;ciloalaMide;Cilostamide,OPC 3689;Cilostamide - CAS 68550-75-4 - Calbiochem;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE;N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide
- 中文名:
- OPC 3689 西洛酰胺
- 中文别名:
- 西洛他胺;西洛酰胺;斯台酰胺;OPC 3689 西洛酰胺;N-环己基-N-甲基-4-((2-氧代-1,2-二氢喹啉-6-基)氧基)丁酰胺;N-环己基-4-[(1,2-二氢-2-氧代-6-喹啉基)氧基]-N-甲基-丁酰胺
- CBNumber:
- CB1444199
- 分子式:
- C20H26N2O3
- 分子量:
- 342.43
- MOL File:
- 68550-75-4.mol
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OPC 3689 西洛酰胺化学性质
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熔点:
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186～188℃
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沸点:
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594.3±50.0 °C(Predicted)
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密度:
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1.18±0.1 g/cm3(Predicted)
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储存条件:
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0-6°C
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溶解度:
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Soluble in DMSO (up to 30 mg/ml).
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形态:
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White solid
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酸度系数(pKa):
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11.12±0.70(Predicted)
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颜色:
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White
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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OPC 3689 西洛酰胺性质、用途与生产工艺
Cilostamide (OPC 3689)是type III phosphodiesterases的抑制剂，对PDE3A 和PDE3B的IC50值分别为27 nM和50 nM。
| Target | Value |
PDE3A
()
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27 nM
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PDE3B
()
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50 nM
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Cilostamide is a selective and potent PDE3 inhibitor, with IC
50
s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Cilostamide weakly inhibits PDE2, PDE4, PDE5, PDE7, and PDE1, with IC
50
s of 12.5, 88.8, 15.2, 22.0 and > 300 μM, respectively. Cilostamide potently inhibits thrombin-induced platelet aggregation (IC
50
, 1.1 μM).
OPC 3689 西洛酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101312 | Cilostamide | | 1 mg | 431元 |
| 2024/04/30 | HY-101312 | OPC 3689 西洛酰胺
Cilostamide | 68550-75-4 | 5mg | 700元 |
68550-75-4, OPC 3689 西洛酰胺 相关搜索:
- Cyclic Nucleotide related
- 合成有机化合物配体
- G Proteins and Cyclic Nucleotides
- Cyclic Nucleotide Metabolism
- Phosphodiesterase Inhibitors
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- N-环己基-N-甲基-4-((2-氧代-1,2-二氢喹啉-6-基)氧基)丁酰胺
- N-环己基-4-[(1,2-二氢-2-氧代-6-喹啉基)氧基]-N-甲基-丁酰胺
- 西洛他胺
- 西洛酰胺
- 斯台酰胺
- OPC 3689 西洛酰胺
- 68550-75-4
- OPC-3689,OPC 3689,Cilostamide,Phosphodiesterase (PDE),Inhibitor,inhibit
- N-Cyclohexyl-N-methyl-4-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)butanamide
- Butanamide, N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-
- Cilostamide - CAS 68550-75-4 - Calbiochem
- N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide
- N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide
- N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutanamide
- 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one
- ciloalaMide
- Cilostamide,OPC 3689
- CILOSTAMIDE
- N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE
- OCP 3689
- OPC 3689