氯唑西林
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- CAS号:
- 61-72-3
- 英文名:
- Cloxacillin
- 英文别名:
- Syntarpen;MCIPC;brl1621;CLOXACILLIN;methocillins;Cloxacillin 13C4;Cloxacillin Impurity;Orbenin Extra Dry Cow;CLOXACILLIN USP/EP/BP;Cloxacillin (base and/or unspecified salts)
- 中文名:
- 氯唑西林
- 中文别名:
- 氯苯西林;氯唑西林;氯唑青霉素;氯唑西林杂质;邻氟苯唑青霉素;一水EP杂质E;苯唑西林杂质26;苯唑青霉素钠杂质E;苯唑西林杂质5(苯唑西林EP杂质E)
- CBNumber:
- CB7163623
- 分子式:
- C19H18ClN3O5S
- 分子量:
- 435.88
- MOL File:
- 61-72-3.mol
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氯唑西林化学性质
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沸点:
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689.7±55.0 °C(Predicted)
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密度:
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1.2954 (rough estimate)
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折射率:
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1.6100 (estimate)
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酸度系数(pKa):
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pKa 2.70±0.07(H2O t=35.0 c=0.0025) (Uncertain)
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InChIKey:
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LQOLIRLGBULYKD-JKIFEVAISA-N
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SMILES:
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N12[C@@]([H])([C@H](NC(C3=C(C)ON=C3C3=CC=CC=C3Cl)=O)C1=O)SC(C)(C)[C@@H]2C(O)=O
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氯唑西林性质、用途与生产工艺
氯唑西林为半合成的耐青霉素酶青霉素。其抗菌作用特点是:对青霉素酶高度稳定(稳定性高于其他耐青霉素酶青霉素类药),对产青霉素酶的葡萄球菌属(包括金黄色葡萄球菌和凝固酶阴性葡萄球菌)的抗菌活性较苯唑西林强,但对青霉素敏感葡萄球菌和各种链球菌的抗菌作用较青霉素弱5~10倍本品为繁殖期杀菌药。
主要用于治疗耐青霉素葡萄球菌所致的感染,包括败血症、心内膜炎、呼吸道感染、皮肤及软组织感染等。也可用于治疗化脓性链球菌或肺炎球菌与耐青霉素葡萄球菌所致的混合感染。
氯唑西林
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61-72-3, 氯唑西林 相关搜索:
- 杂质
- 其它杂质
- 氯唑西林杂质
- 医药原料药
- C19H18CL1N3O5S1
- C19H16N3ClO5S
- C19H18ClN3O5S
- 60-72-3
- 苯唑西林杂质26
- 一水EP杂质E
- 苯唑西林杂质5(苯唑西林EP杂质E)
- 苯唑青霉素钠杂质E
- 氯唑西林杂质
- 氯唑青霉素
- 氯苯西林
- 氯唑西林
- 邻氟苯唑青霉素
- 61-72-3
- Oxacillin Impurity 5 (Oxacillin EP Impurity E)
- Cloxacillin Impurity
- (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid(cloxacillin),
- Syntarpen
- CloxacillinQ: What is
Cloxacillin Q: What is the CAS Number of
Cloxacillin
- Cloxacillin 13C4
- CLOXACILLIN USP/EP/BP
- xo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid
- methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,(2s-(2alpha,5alpha,6b
- methocillins
- brl1621
- 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]penicillanicacid
- 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-o
- 6-(((3-(2-chlorophenyl)-5-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci
- CLOXACILLIN
- 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(3-(o-chlorophenyl)-5-me
- 3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-
- [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin
- (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-7-keto-3,3-dimethyl-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- MCIPC
- (2S,5β)-6α-[[[3-(2-Chlorophenyl)-5-methylisoxazole-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2β-carboxylic acid
- (2S,5R,6R)-6-[[[5-Methyl-3-(2-chlorophenyl)-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-1-aza-4-thiabicyclo[3.2.0]heptane-2-carboxylic acid
- Cloxacillin (base and/or unspecified salts)
- Orbenin Extra Dry Cow
- 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid
- 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- 6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid
- 6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo- (8CI)
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
- 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(3-(o-chlorophenyl)-s-me