Sodium carboxyl methylstarch

Sodium carboxyl methylstarch Struktur
9063-38-1
CAS-Nr.
9063-38-1
Englisch Name:
Sodium carboxyl methylstarch
Synonyma:
SODIUM STARCH GLYCOLATE;Primojel;CMS-Na;CARBOXYMETHYL STARCH SODIUM;explotab;SODIUM STARCH GLYCOLLATE;PRIMOJEL(R);Sodium Starch g;Sodium Starch GL;Carboxy methyl starc
CBNumber:
CB0189314
Summenformel:
C2H4O3·xNa·x
Molgewicht:
0
MOL-Datei:
Mol file

Sodium carboxyl methylstarch Eigenschaften

Schmelzpunkt:
>210°C (dec.)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
Practically insoluble in methylene chloride. It gives a translucent suspension in water.
Farbe
White to Off-White
CAS Datenbank
9063-38-1
EPA chemische Informationen
Starch, carboxymethyl ether, sodium salt (9063-38-1)

Sicherheit

WGK Germany  1
HS Code  3505100092

Sodium carboxyl methylstarch Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White or almost white, fine, free-flowing powder, very hygroscopic.

Verwenden

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either directcompression or wet-granulation processes.

Vorbereitung Methode

Sodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also crosslinked using either sodium trimetaphosphate (Types A and B) or dehydration (Type C).
Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline, nonaqueous medium, typically denatured ethanol or methanol, followed by neutralization with citric acid, acetic acid, or some other acid. Vivastar P is manufactured in methanolic medium, and Explotab in ethanolic medium.

Pharmazeutische Anwendungen

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. The usual concentration employed in a formulation is between 2% and 8%, with the optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.
Although the effectiveness of many disintegrants is affected by the presence of hydrophobic excipients such as lubricants, the disintegrant efficiency of sodium starch glycolate is unimpaired. Increasing the tablet compression pressure also appears to have no effect on disintegration time.
Sodium starch glycolate has also been investigated for use as a suspending vehicle.

Sicherheit(Safety)

Sodium starch glycolate is widely used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may be harmful.

Lager

Tablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.
The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity.

Inkompatibilitäten

Sodium starch glycolate is incompatible with ascorbic acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium carboxyl methylstarch Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sodium carboxyl methylstarch Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 350)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386
marketing1@neostarunited.com China 8350 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666
sales@hbmojin.com China 12409 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850
admin@hbjingbo.cn China 1000 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 14770 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763
info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29919 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282
alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58

9063-38-1()Verwandte Suche:


  • sodium carboxyl methylstarch
  • PRIMOJEL(R)
  • CARBOXYMETHYL STARCH SODIUM SALT
  • SodiumStarchGlycolateExtraPure
  • SODIUMSTARCHGLYCOLATE,PH5.5-7.5,NF
  • Carboxymethylstrke, Natriumsalz
  • SODIUM STARCH GLYCOLATE USP 24
  • SODIUM STARCH GLYCOLATE USP/NF
  • sodium carboxymethoxy starch
  • Sodium Starch Glycolate Type A (400 mg)
  • Sodium Starch Glycolate Type B (400 mg)
  • Carboxy methyl starc
  • SodiuM Starch Glycolate, pH 5.5-7.5, Type A, NF
  • CarboTab MCR (Carboxymethylstarch sodium)
  • Starch, carboxymethyl ether, monosodium salt
  • SodiuM starch glycolate NF
  • Sodium starch glycolate type B
  • Carboxy Methyl starch sodiuM (CMS)
  • SODIUM STARCH GLYCOLATE (MAIZE & POTATO)
  • Sodiumcarboxymethylstarch
  • Sodiumcarboxymethylstarchmedicinal
  • Starch,carboxymethylether,sodiumsalt
  • Carboxy methyl starch sodium (CMS), AR
  • Sodium Starch g
  • Sodium Starch GL
  • Sodium carboxyl methylstarch USP/EP/BP
  • sodium starch glycolate (SSG)
  • Sodium Starch Glycolate ex. Maize (SSG) ExiPlus, Multi-Compendial
  • SODIUM STARCH GLYCOLATE
  • SODIUM STARCH GLYCOLLATE
  • CARBOXYMETHYL STARCH SODIUM
  • Primojel
  • CMS-Na
  • explotab
  • Sodium carboxymethyl starc
  • Carboxyl methylstarch (sodium)
  • 9063-38-1
  • C2H4O3xNax
  • 9063-38-1
  • bc0001
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