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Sodium carboxyl methylstarch

CAS No.
9063-38-1
Chemical Name:
Sodium carboxyl methylstarch
Synonyms
SODIUM STARCH GLYCOLATE;Primojel;CMS-Na;CARBOXYMETHYL STARCH SODIUM;explotab;SODIUM STARCH GLYCOLLATE;PRIMOJEL(R);Sodium Starch g;Sodium Starch GL;Carboxy methyl starc
CBNumber:
CB0189314
Molecular Formula:
C2H4O3·xNa·x
Molecular Weight:
0
MDL Number:
MFCD00217761
MOL File:
Mol file
Last updated:2023-11-27 13:03:33

Sodium carboxyl methylstarch Properties

Melting point >210°C (dec.)
storage temp. Inert atmosphere,Room Temperature
solubility Practically insoluble in methylene chloride. It gives a translucent suspension in water.
color White to Off-White
CAS DataBase Reference 9063-38-1
FDA UNII SODIUM STARCH GLYCOLATE TYPE B CORN (2LI18Q1ZCG)
SODIUM STARCH GLYCOLATE TYPE B POTATO (27NA468985)
SODIUM STARCH GLYCOLATE TYPE A POTATO (5856J3G2A2)
SODIUM STARCH GLYCOLATE TYPE A CORN (AG9B65PV6B)
SODIUM STARCH GLYCOLATE TYPE A (H8AV0SQX4D)
EPA Substance Registry System Starch, carboxymethyl ether, sodium salt (9063-38-1)

SAFETY

Risk and Safety Statements

WGK Germany  1
HS Code  3505100092

Sodium carboxyl methylstarch price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1614670 Sodium starch glycolate type B 9063-38-1 400mg $497 2024-03-01 Buy
Sigma-Aldrich 1614669 Sodium Starch Glycolate Type A 9063-38-1 400mg $522 2024-03-01 Buy
TRC S666990 SodiumStarchGlycolate 9063-38-1 100mg $100 2021-12-16 Buy
TRC S666990 SodiumStarchGlycolate 9063-38-1 5g $275 2021-12-16 Buy
Usbiological 166567 Sodium Starch Glycolate 9063-38-1 100mg $403 2021-12-16 Buy
Product number Packaging Price Buy
1614670 400mg $497 Buy
1614669 400mg $522 Buy
S666990 100mg $100 Buy
S666990 5g $275 Buy
166567 100mg $403 Buy

Sodium carboxyl methylstarch Chemical Properties,Uses,Production

Chemical Properties

Sodium starch glycolate is a white or almost white free-flowing very hygroscopic powder. The PhEur 6.0 states that when examined under a microscope it is seen to consist of: granules, irregularly shaped, ovoid or pear-shaped, 30–100 mm in size, or rounded, 10–35 mm in size; compound granules consisting of 2–4 components occur occasionally; the granules have an eccentric hilum and clearly visible concentric striations. Between crossed nicol prisms, the granules show a distinct black cross intersecting at the hilum; small crystals are visible at the surface of the granules. The granules show considerable swelling in contact with water.

Chemical Properties

White or almost white, fine, free-flowing powder, very hygroscopic.

Uses

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either directcompression or wet-granulation processes.

Uses

Sodium Starch Glycolate is a starch of potato origin with α1-4 short linear linkages and branched α1-6 linkages between glucose units. Used in the synthesis of capsules for delivery of drugs or medicaments.

Production Methods

Sodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also crosslinked using either sodium trimetaphosphate (Types A and B) or dehydration (Type C).
Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline, nonaqueous medium, typically denatured ethanol or methanol, followed by neutralization with citric acid, acetic acid, or some other acid. Vivastar P is manufactured in methanolic medium, and Explotab in ethanolic medium.

Pharmaceutical Applications

Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. The usual concentration employed in a formulation is between 2% and 8%, with the optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.
Although the effectiveness of many disintegrants is affected by the presence of hydrophobic excipients such as lubricants, the disintegrant efficiency of sodium starch glycolate is unimpaired. Increasing the tablet compression pressure also appears to have no effect on disintegration time.
Sodium starch glycolate has also been investigated for use as a suspending vehicle.

Safety

Sodium starch glycolate is widely used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may be harmful.

storage

Tablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.
The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity.

Incompatibilities

Sodium starch glycolate is incompatible with ascorbic acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium carboxyl methylstarch Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 350)Suppliers
Supplier Tel Email Country ProdList Advantage
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386 marketing1@neostarunited.com China 8350 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 admin@hbjingbo.cn China 1000 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
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career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58

View Lastest Price from Sodium carboxyl methylstarch manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium carboxyl methylstarch pictures 2023-12-25 Sodium carboxyl methylstarch
9063-38-1
US $10.00 / kg 1kg 99% 200000 Hebei Jingbo New Material Technology Co., Ltd
Sodium carboxyl methylstarch pictures 2023-09-06 Sodium carboxyl methylstarch
9063-38-1
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
Sodium carboxyl methylstarch pictures 2023-08-18 Sodium carboxyl methylstarch
9063-38-1
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
sodium carboxyl methylstarch PRIMOJEL(R) CARBOXYMETHYL STARCH SODIUM SALT SodiumStarchGlycolateExtraPure SODIUMSTARCHGLYCOLATE,PH5.5-7.5,NF Carboxymethylstrke, Natriumsalz SODIUM STARCH GLYCOLATE USP 24 SODIUM STARCH GLYCOLATE USP/NF sodium carboxymethoxy starch Sodium Starch Glycolate Type A (400 mg) Sodium Starch Glycolate Type B (400 mg) Carboxy methyl starc SodiuM Starch Glycolate, pH 5.5-7.5, Type A, NF CarboTab MCR (Carboxymethylstarch sodium) Starch, carboxymethyl ether, monosodium salt SodiuM starch glycolate NF Sodium starch glycolate type B Carboxy Methyl starch sodiuM (CMS) SODIUM STARCH GLYCOLATE (MAIZE & POTATO) Sodiumcarboxymethylstarch Sodiumcarboxymethylstarchmedicinal Starch,carboxymethylether,sodiumsalt Carboxy methyl starch sodium (CMS), AR Sodium Starch g Sodium Starch GL Sodium carboxyl methylstarch USP/EP/BP sodium starch glycolate (SSG) Sodium Starch Glycolate ex. Maize (SSG) ExiPlus, Multi-Compendial SODIUM STARCH GLYCOLATE SODIUM STARCH GLYCOLLATE CARBOXYMETHYL STARCH SODIUM Primojel CMS-Na explotab Sodium carboxymethyl starc Carboxyl methylstarch (sodium) 9063-38-1 C2H4O3xNax 9063-38-1 bc0001