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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Struktur
493028-20-9
CAS-Nr.
493028-20-9
Englisch Name:
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
Synonyma:
CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber:
CB0412427
Summenformel:
C12H14N2OS
Molgewicht:
234.32
MOL-Datei:
Mol file
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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Eigenschaften

Siedepunkt:
421.6±40.0 °C(Predicted)
Dichte
1.192±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
Löslichkeit
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
Aggregatzustand
Tan solid
pka
5.00±0.10(Predicted)

Sicherheit

Kennzeichnung gefährlicher Xi
HazardClass  IRRITANT

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

Verwenden

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 30)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
BOC Sciences 16314854226
 info@bocsci.com United States 9926 65
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
 sales@hopschem.com China 31557 55
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725
 malulu@leyan.com China 55023 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8141 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8618 58
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24017 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715
 sales@szzxbio.com China 2992 58
  • TIMTEC-BB SBB011699
  • 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
  • CBFβ Inhibitor
  • 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
  • CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
  • CBFβ Inhibitor
  • 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
  • Runx1-CBFβ interaction inhibitor 1
  • 493028-20-9
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