7BIO

916440-85-2

CAS-Nr.: 916440-85-2

Englisch Name:: 7BIO

Synonyma:: 7BIO;7BIO - CAS 916440-85-2 - Calbiochem;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3

CBNumber:: CB33136738

Summenformel:: C16H10BrN3O2

Molgewicht:: 356.17

MOL-Datei:: 916440-85-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 46

7BIO Eigenschaften

storage temp.: +2C to +8C

Löslichkeit: Soluble in ethanol;DMSO

Aggregatzustand: Deep black-red solid

Farbe: Dark red

Sicherheit

7BIO Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC₅₀ = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC₅₀s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC₅₀ values of 4.6 and 0.7 μM, respectively.

7BIO Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7BIO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 46)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9708	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3500	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2992	58

7BIO
7BIO - CAS 916440-85-2 - Calbiochem
2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3
7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
916440-85-2