PROSTAGLANDIN A1
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- CAS-Nr.
- 14152-28-4
- Englisch Name:
- PROSTAGLANDIN A1
- Synonyma:
- PGA1;Prostaglandin A;Prostagladin E1;C04685;pga(sub1);pga(sup1);Prostagladin A;PROSTAGLANDIN A1;PROSTAGLANDINS A1;prostaglandina(sup1)
- CBNumber:
- CB3666883
- Summenformel:
- C20H32O4
- Molgewicht:
- 336.47
- MOL-Datei:
- 14152-28-4.mol
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PROSTAGLANDIN A1 Eigenschaften
- Schmelzpunkt:
- 43°C
- Siedepunkt:
- 392.93°C (rough estimate)
- Dichte
- 1.0192 (rough estimate)
- Brechungsindex
- 1.4434 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- acetone: 10 mg/mL, clear
- Aggregatzustand
- White solid.
- pka
- 4.77±0.10(Predicted)
- Farbe
- Off-white
- BRN
- 2003401
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
PROSTAGLANDIN A1 Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Prostaglandin A
1 (PGA
1) was first isolated as a dehydration product of the PGE
1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-
inhibitory activity on tumor cells; the IC
50 value for the inhibition of human ovarian cancer is 7.5 μM.
Verwenden
Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.
Allgemeine Beschreibung
Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).
Enzyminhibitor
This eicosanoid (FWfree-acid = 336.47 g/mol; CAS 14152-28-4; Symbol: PGA1) induces apoptosis and stimulates the expression of stress genes. The structure and role of the prostaglandin A1 was investigated by Bergstr?m and Samuelsson, who shared the 1982 Nobel Prize in Physiology or Medicine for their pioneering work on the eicosanoids. Target(s): CYP4F2; DNA topoisomerase II; HIV-1 transcription; 3ahydroxysteroid dehydrogenase, NADP+-dependent; IkB kinase; Mayaro virus replication; stress-induced NF-kB activation; and virus protein biosynthesis, or translation.
PROSTAGLANDIN A1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PROSTAGLANDIN A1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 75)Lieferanten
14152-28-4()Verwandte Suche:
- prostaglandina(sup1)
- prostaglandine(sup1)-217
- prostaglandina1syntheticcrystalline
- (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
- (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate
- C04685
- ProstaglandinA1,(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
- Prostaglandin A1 (25 mg)
- Prostaglandin Impurity A
- PGA1 (Prostaglandin A1)
- prostaglandins A1 synthetic
- 9-OXO-15S-HYDROXY-PROSTA-10,13E-DIEN-1-OIC ACID
- [13E,15S]-15-HYDROXY 9-OXOPROSTA-10,13-DIEN-1-OIC ACID
- PROSTAGLANDINS A1
- PROSTAGLANDIN A1
- 13-dien-1-oicacid,15-hydroxy-9-oxo-,(13e,15s)-prosta-1
- 2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentene-1-heptanoicaci
- pga(sub1)
- pga(sup1)
- prostaglandina(sub1)
- Prostagladin A
- Alprostadil (Prostaglandin E1) EP Impurity A
- Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
- Prostaglandin A1 (1578500)
- Prostaglandin A
- Prostagladin E1
- PGA1
- a.7-[(1R,2S)-2-[(1e,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-enyl]heptanoicacid(prostaglandina1)
- Prostaglandin (Alprostadil) EP Impurity A
- 14152-28-4
- 33647
- BioChemical
- Biochemicals and Reagents
- Fatty Acids
- Prostaglandins
- Lipids
