Methyltestosteron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R22:Gesundheitsschädlich beim Verschlucken.
R20:Gesundheitsschädlich beim Einatmen.
R19:Kann explosionsfähige Peroxide bilden.
R11:Leichtentzündlich.
R61:Kann das Kind im Mutterleib schädigen.
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Beschreibung
Methyltestosterone is a synthetic analog of testosterone that possesses all of the properties of
testosterone, exhibiting stimulatory action on the development of male sex organs and secondary sex characteristics, although it is not degraded by enzymes in the gastrointestinal
tract, and therefore it can only be taken orally
Chemische Eigenschaften
white to slightly yellowish-white crystalline
Verwenden
Androgen. It has been used as an androgenic agent.
Controlled substance (anabolic steroid).
Definition
ChEBI: A 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.
Pharmakokinetik
The synthesis of 17α-methyltestosterone made available a compound that was orally active in
daily doses between 10 and 50 mg, which is equivalent to a 400 mg oral dose of testosterone. The
presence of a 17α alkyl group reduces susceptibility to hepatic oxidative metabolism, thereby
increasing oral bioavailability by slowing metabolism. Following oral administration,
methyltestosterone is well absorbed from the gastrointestinal tract, with a half-life of approximately 3
hours. This drug has the androgenic and anabolic activities of testosterone. Although orally active, it
is more effective when administered sublingually. The alkylated oral androgens should be viewed as
potentially hepatotoxic and should not be used.
Sicherheitsprofil
Poison by
intraperitoneal route. Moderately toxic by
ingestion. Human teratogenic effects by
ingestion: developmental abnormalities of
the urogenital system. Experimental
teratogenic and reproductive effects. Human
systemic effects: cholestatic jaundce, weight
loss or decreased weight gain. Questionable human carcinogen producing liver tumors.
A synthetic androgenic steroid. When
heated to decomposition it emits acrid
smoke and irritating fumes.
läuterung methode
This anabolic steroid is crystallised from hexane or hexane/*benzene. It has E1cm 1% 495-530 at 241nm (EtOH). The colour reaction with 2,4-dinitrophenyl hydrazine is used for assaying it. [Gornall & Macdonald J Biol Chem 201 279 1953.] In another colour reaction the sterone (1mg) in acetic acid (0.2ml) + 88% H3PO4 (2mL) is allowed to stand for 1hour when it becames fluorescent. After 1hour it is diluted with acetic acid (~3mL) and provides a strong yellow fluorescence with the intensity of 50-100 times that of estrone. [Stuart & Stuckey J Pharm Pharmacol 1 130 1949, Openauer Rec Trav Chim Pays-Bas 56 137 137, Beilstein 8 IV 1010.]
Methyltestosteron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
