CAY10618

1202580-59-3

CAS-Nr.: 1202580-59-3

Englisch Name:: CAY10618

Synonyma:: GPP 78;CAY10618;GPP78,GPP-78;CAY10618 Exclusive;N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide;1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-

CBNumber:: CB42590444

Summenformel:: C27H29N5O

Molgewicht:: 439.55

MOL-Datei:: 1202580-59-3.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 27

CAY10618 Eigenschaften

Dichte: 1.15±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 10 mg/ml

pka: 14.80±0.70(Predicted)

Sicherheit

CAY10618 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD⁺ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD⁺ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC₅₀ = 3 nM). It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC₅₀ value of 3.8 nM through a process that appears to involve autophagy.

CAY10618 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CAY10618 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 27)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Chengdu Peter-like Biotechnology Co., Ltd.	028-81700200 18108052721	2850505130@qq.com	China	5182	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58

CAY10618
1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-
GPP 78
CAY10618 Exclusive
N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide
GPP78,GPP-78
1202580-59-3