Irbesartan
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- CAS-Nr.
- 138402-11-6
- Englisch Name:
- Irbesartan
- Synonyma:
- AVAPRO;Lrbesartan;Irbesatan;Irbesartan Impurity 1;3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;APROVEL;CS-1097;SR-47436;Irbesarta;BMS-186295
- CBNumber:
- CB4454663
- Summenformel:
- C25H28N6O
- Molgewicht:
- 428.53
- MOL-Datei:
- 138402-11-6.mol
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Irbesartan Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Avapro was launched in Germany, the UK and the US for hypertension. It
can be prepared in six steps starting with cyclopentanone or in three steps from 1-
aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro is
an angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT,
subtypes and has no AT
2 activity at postsynaptic receptors compared to presynatpic. It
has no affinity for various non angiotensin Ⅱ receptor types in binding, no interaction
with calcium channels or antiports, and no affinity for α
1- and α
2--adrenoreceptors,
serotonergic receptors, muscarinic m
1 and m
2 or other receptors. It is as potent as
saralasin but with no agonist activity and is 10 times more potent than DuP753 in rats.
It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol,
while more effective than losartan for mild to moderate hypertension.
Chemische Eigenschaften
Crystalline Solid
Verwenden
For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges
Definition
ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Allgemeine Beschreibung
Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.
Irbesartan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Irbesartan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 782)Lieferanten
- 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE
- IRBESARTAN
- BMS-186295
- APROVEL
- 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 2-Isopropryl-4-methylthiazole
- 2-butyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- 2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- 2-butyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- 2-Isopropryl-4-methylthiazole (Irbesartan)
- Irbesartan (200 mg)
- Irbesartan(Avapro)
- 2-butyl-3-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
- 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
- Irbesartan Synonyms 3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
- 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
- 2N-Butyl-4-spirocyclopentane-2-imidazolin-5-one hydrochloride
- IrbesartanC25H28N6O
- 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE
- 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, BMS-186295, SR-47436, Aprovel, Avapro
- IRBESARTAN/3-BYTY1-3-[P-(0-1H-TETRAZOL-5-Y1-PHENY1)BENZY1],3-DIAZOSPIRO[4,4]NON-1-EN-4-KETONE
- 2-N-BUTYL-4-SPIROCYCLOPENTANE-1-[(2-CYANOBIPHENYL-4-YL)METHYL]-2-IMIDAZOLIN-5-ONE(IRBESARTAN)
- 2-buty1-3-[p-(0-1H-tetrazol-5-y1-pheny1)benzy1]1,3-diazospiro[4,4]non-1-en-4-ketone
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-
- Irbersartan
- 2-BUTYL-3-[2''-(1H-TETRAZOL-5-YL)BIPHENYL-4-YLMETHYL]1,3-DIAZA-SPIRO[4.4]NON-1-EN-4-ONE
- 2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-
- Irbesarta
- 2-Butyl-3-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1，3-diazaspiro[4.4]non-1-en-4-one
- SR-47436
- CS-1097
- AVAPRO; SR-47436; BMS-186295
- ebeisaotan
- 2-butyl-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
- Irbesartan (SR-47436
- Irbesartan, 99%, a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist
- Irbesartan Control
- Irbesartan>
- Irbesartan CRS
- Irbesartan USP/EP/BP
- Irbesartan (1347700)
- 3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
- AVAPRO
- Irbesatan
- Lrbesartan
- Irbesartan Impurity 1
- tert-Butyl peroxybenzoate 614-45-9
- IRBESARTAN 50% GRANULES
- Irbesartan
2-Butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3- diazaspiro[4.4]non-1-en-4-one
- Irbesartan Reference Standard
- 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
- 138402-11-6
- C25H28N6O
- 42854
- C25H28ON6
