benzomalvin A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Benzomalvin A is a fungal metabolite produced by
Penicillium. It inhibits yeast α-glucosidase
in vitro (IC
50 = 383.2 μM).
In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK
1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK
1 (K
is = 12, 42, and 43 μM, respectively).
benzomalvin A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
