Δ4-Dafachronic acid

Δ4-Dafachronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ⁴-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12. Δ⁴-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults. The (25S) diastereomer of Δ⁴-dafachronic acid is significantly more potent than its (25R) counterpart (EC₅₀s = 23 and 66 nM, respectively).

Δ4-Dafachronic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Δ4-Dafachronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

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