2'-Desoxycytidin
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- CAS-Nr.
- 951-77-9
- Bezeichnung:
- 2'-Desoxycytidin
- Englisch Name:
- 2'-Deoxycytidine
- Synonyma:
- DC;deoxycytidine;4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one;dCyd;2-Deoxycystidine;Cytosine deoxyribonucleoside;4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one;2'-DC;2'Isomer Only)
- CBNumber:
- CB7452978
- Summenformel:
- C9H13N3O4
- Molgewicht:
- 227.22
- MOL-Datei:
- 951-77-9.mol
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2'-Desoxycytidin Eigenschaften
- Schmelzpunkt:
- 209-211 °C(lit.)
- Siedepunkt:
- 368.93°C (rough estimate)
- Dichte
- 1.3171 (rough estimate)
- Brechungsindex
- 59 ° (C=1, H2O)
- storage temp.
- -20°C
- Löslichkeit
- H2O: 50 mg/mL, clear, colorless
- Aggregatzustand
- Crystalline Powder
- pka
- 14.03±0.60(Predicted)
- Farbe
- White
- Wasserlöslichkeit
- Soluble in water, DMSO.
- BRN
- 87567
- InChI
- InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
- InChIKey
- CKTSBUTUHBMZGZ-SHYZEUOFSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)C[C@@H]1O
- CAS Datenbank
- 951-77-9(CAS DataBase Reference)
- NIST chemische Informationen
- Deoxycytidine(951-77-9)
- EPA chemische Informationen
- Cytidine, 2'-deoxy- (951-77-9)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
HA3800000 |
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| F |
10 |
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| TSCA |
Yes |
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| HS Code |
29349990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
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2'-Desoxycytidin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White crystalline powder
Verwenden
A deoxyribonucleoside
Definition
ChEBI: A pyrimidine 2'-deoxyribonucleoside having cytosine as the nucleobase.
Allgemeine Beschreibung
2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.
Sicherheitsprofil
Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx.
läuterung methode
Purify 2'-deoxycytidine by recrystallisation from MeOH/Et2O or EtOH and dry it in air. [NMR: Miles J Am Chem Soc 85 1007 1963, UV: Fox & Shugar Biochim Biophys Acta 9 369 1952.] The hydrochloride crystallises from H2O/EtOH and has m 174o(dec, 169-173o). [Walker & Butler Can J Chem 34 1168 1956.] The picrate has m 208o(dec). [Fox et al. J Am Chem Soc 83 4066 1961, Beilstein 25 III/IV 3662.]
Structure and conformation
2'-Deoxycytidine monohydrate (dCMP) is a nucleoside phosphate in being comprised of a deoxyribonucleoside and one phosphate group. It has a deoxyribose as its sugar constituent with one phosphate group attached. Its nucleoside contains a pyrimidine base, i.e., a cytosine attached to the deoxyribose sugar. It has only one phosphate group attached to the nucleoside. Its conjugate acid form is deoxycytidylic acid, whereas its conjugate base form is deoxycytidylate. dCMP, instead of having a hydroxyl group on the 2′ carbon of the sugar component as it is in Cytidine monophosphate (CMP), has it reduced to a hydrogen atom (thus, deoxy- in its name). dCMP is one of the monomeric units that constitute DNA, whereas CMP is one of the monomeric units that make up RNA.
2'-Desoxycytidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-Desoxycytidin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 461)Lieferanten
951-77-9(2'-Desoxycytidin)Verwandte Suche:
- 2''-DEOXYCYTIDINE (CYTOSINE): (DEOXYRIBOSIDE)
- 2-DEOXYCYTIDINE extrapure
- 2'-Deoxycytidine ,98%
- 2'-Deoxycytidine(dC)
- 1-(2-Deoxy-β-D-ribofuranosyl)cytosine
- 4-AMino-1-(2-deoxy-β-D-erythro
-pentofuranosyl)-2(1H)-pyriMidinone
- 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
- 2'-DEOXYCYTIDINE FREE BASE
- 2''-Deoxycytidine (and/or unspecified salts)
- 2'-Deoxycytidine monohydrate
- 1-(2-Deoxy-beta-D-ribofuranosyl)cytosine
dC
- (2R,3R,4S,5R)-2-(4-aMino-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol
- 2’-deoxy-cytidin
- Cytidine, 2'-deoxy-
- Cytosine, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
- cytosine,deoxyribonucleoside
- Deoxyribose cytidine
- deoxyribosecytidine
- Desoxycytidine
- 2'-DEOXY-D-CYTIDINE
- 2'-DC
- CYTOSINE DEOXYRIBOSIDE
- 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)CYTOSINE
- 2&apos
- 4-amino-1-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidin-2-one
- 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-
- 4-amino-1-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-pyrimidinone
- 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
- 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
- Deoxycytidine-2-14C
- 3,N4-Etheno-2&rsquo
- 5,6-Dihydro-5-aza-2&rsquo
- N4-[(Dimethylamino)methylidene]-5-[3-oxo-[[6-[(trifluoroacetyl)amino]hexyl]amino]-1-propenyl]-2&rsquo
- -deoxy-6-oxo Cytidine
- -deoxyuridine (&beta
- Isomer Only)
- 5-Aza-2&rsquo
- N4-Benzoyl-5-(furan-2-yl)-2&rsquo
- -Deoxycytidine monohydrate
- Cytarabine Impurity 20（2'-Deoxycytidine）
- N4-Ethyl-2&rsquo
- 5-[(2-Cyanoethoxy)methyl]-2&rsquo
- 2-Thio-2&rsquo
- 5-Chloro-2&rsquo
- 4-Amino-1-(2-deoxy-B-D-erythropentofuranosyl)-1,3,5-triazin-2(1H)-one)
- Decitabine, DNA Methyltransferase Inhibitor|(5-Aza-2&rsquo
- -Deoxy-5-azacytidine
- 5-Carboethoxy-2&rsquo
- Deoxycytidine Deoxycytidine
- 2'-Deoxycytidine>
- 2'-Deoxycytidine monohydrate USP/EP/BP
- 951-77-9 USP/EP/BP
- 4-Amino-1-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
- 2-Deoxycystidine
- 4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one
- 4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one
- Cytosine deoxyribonucleoside
- dCyd
