Oxymorphon

Oxymorphon Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystalline Solid

Verwenden

Controlled substance (opiate). Analgesic (narcotic)

Biologische Funktion

Oxymorphone is 10 times as potent as morphine, with actions similar to those of hydromorphone. Oxymorphone, however, has little antitussive activity, and as such is a useful analgesic in patients with pulmonary disease who need to retain the ability to cough.

Allgemeine Beschreibung

Oxymorphone is the 14 beta-hydroxyl version of hydromorphone,analogous to the hydrocodone, oxycodone pair discussedabove. Although the addition of the 14 beta-hydroxylgroup to hydrocodone (30 mg) yielded oxycodone (20 mg),a more potent drug, the opposite is true for the conversion ofhydromorphone (7.5 mg) to oxymorphone (10 mg). The reasonfor this is that the oral bioavailability of oxymorphone(10%) is lower than that of hydromorphone (35%) becauseof decreased absorption and increased first-pass metabolism.Presumably, the addition of the OH group does increaseits binding affinity at the receptor as the injectableform of oxymorphone (1 mg) is more potent than injectablehydromorphone (1.5 mg).
Oxymorphone is available as a suppository (5 mg), an injection(1 mg/mL), an immediate-release tablet (5 mg, 10mg), and in 2003 the FDA approved a sustained release formulation(Opana ER 5 mg, 10 mg, 20 mg, and 40 mg). The12-hour coverage of the extended release tablet provides anotheroption for those patients suffering from chronic pain.The side effect profile of the extended release formulationsof morphine, oxycodone, and oxymorphone are similar, andthere appears to be no clear advantage of one over the other.

Oxymorphon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

76-41-5(Oxymorphon)Verwandte Suche:

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• (5a)-4,5-Epoxy-3,14-dihydroxy-17-methyl-morphinan-6-one
• NIH 10323
• NSC 19045
• 4,5-Epoxy-3,14-dihydroxy-N-methyl-6-oxomorphinan
• OXYMORPHONE (MW 301.35)
• Oxymorphone (base and/or unspecified salts)
• (14S)-14-Hydroxydihydromorphinone
• 14-Hydroxydihydromorphinone
• 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-morphinan-6-on
• 3,14-Dihydroxy-4,5-alpha-epoxy-17-methylmorphinan-6-one
• 4,5alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
• 5-epoxy-3,14-dihydroxy-17-methyl-(5-alpha)-morphinan-6-on
• 7,8-Dihydro-14-hydroxymorphinone
• Dihydro-14-hydroxymorphinone
• Dihydro-14-hydroxymorphinonel 14-hydroxydihydromorphinone
• Dihydrohydroxymorphinone
• Dihydroxymorphinone
• Morphinan-6-one, 3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-
• Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy-17-methyl-
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5alpha)-
• Morphinone, dihydro-14-hydroxy-
• Numorphan
• Oxymorphine
• OXYMORPHONE
• Oxymorphone CII (500 mg)
• Oxymorphone solution
• 4,5α-Epoxy-3,14-dihydoroxy-17-methylmorphinan-6-one
• 4,5α-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one
• Oxymorphone (CRM)
• (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
• Oxymorphone (controlled)
• Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, (5α)-
• Oxymorphone CII (1488000)
• Oxymorphone in Methanol(Solution)
• Morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-methyl-, (5α)-
• 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one(oxymorphone),
• Naltrexone Impurity 15
• Hydroxycodone EP Impurity A
• Nafamostat mesylate impurity G
• Sodium naloxone impurity G
• Oxymorphone CII (300 mg)
• 76-41-5
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Chiral Reagents