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Glaucoma Drug Side effects Glaucoma commonly used drugs Bimatoprost - timolol maleate compound eye drops
Chemical Name:
LUMIGAN;BiMapnost;Prostamide;BIMATOPROST;BIMATOPROST(TM);Bimatoprost API;cGMP Bimatoprost;BIMATOPROST(LUMIGAN);Bimatoprost, >=99.5%;BiMatoprost HOUSE STANDARD
Molecular Formula:
Formula Weight:
MOL File:

Bimatoprost Properties

Melting point:
storage temp. 
CAS DataBase Reference
155206-00-1(CAS DataBase Reference)


WGK Germany  3

Bimatoprost price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P6740 17-Phenyl-tri-norprostaglandin F2α-ethyl amide ≥95%, solid 155206-00-1 1mg $126 2017-11-08 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 5mg $203 2017-11-08 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 1mg $45 2017-11-08 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 10mg $293 2017-11-08 Buy
Cayman Chemical 16820 17-phenyl trinor Prostaglandin F2α ethyl amide ≥97% 155206-00-1 50mg $731 2017-11-08 Buy

Bimatoprost Chemical Properties,Uses,Production

Glaucoma Drug

Bimatoprost is a synthetic amide F2α derivative ,it can selectively simulate the effect forefront amines produced by the body, which make aqueous humor production rate increase aqueous outflow resistance is reduced, by increasing the amount of aqueous outflow of the uveoscleral and trabecular Netcom channel to reduce intraocular pressure (IOP),it is considered to be the most effective hypotensive drug of topical ocular anti-glaucoma drugs,it is suitable for the treatment of open-angle glaucoma (POAG) or invalid elevated intraocular other ocular hypotensive medications compression syndrome (OHT) patients.

Side effects

1. to deepen the color of the iris, blepharitis, eye irritation and pain; black eyelashes thicker growth; conjunctival hyperemia, temporarily punctate corneal epithelial erosion, eyelid edema and erythema; rash.
2. rare respiratory disorders, asthma exacerbations, iritis, uveitis, eyelid skin darkening.
3. very rare chest pain, pharyngitis.
4. eye itching, allergic conjunctivitis, cataract, conjunctival edema, secretions, photophobia, superficial punctate keratitis, headache, high blood pressure.

Glaucoma commonly used drugs

1. prostaglandin derivatives such as latanoprost (Xalatan), bimatoprost (trade name Lumigan) and travoprost (Travatan) can increase outflow of aqueous humor uveoscleral . Bimatoprost also increases trabecular outflow.
2. topical β-adrenergic such as timolol, levobunolol (Betagan), and betaxolol can decrease receptor antagonist of aqueous humor production of ciliary body .
3. Alpha2-adrenergic agonists such as brimonidine (Alphagan) with dual working mechanism, can reduce aqueous humor production and increase trabecular outflow.
4. one case of the selective reduction similar to epinephrine and dipivefrin (Propine) increase outflow of aqueous humor through trabecular meshwork and possibly through uveoscleral outflow pathway, probably by a β2-agonist action.
5. miotic agents (parasympathomimetics), if ciliary muscle contraction Roca works, it can tighten the trabecular and allow increaseing outflow of aqueous humor. Ecothiopate is used for chronic glaucoma.
6. dorzolamide (Trusopt), brinzolamide (Azopt), by inhibiting carbonic anhydrase acetazolamide of ciliary body, reduce aqueous humor secretion of carbonic anhydrase inhibitors.
7. Physostigmine is also used to treat glaucoma and delayed gastric emptying.
The above information is edited by the Chemicalbook of Tian Ye.

Bimatoprost - timolol maleate compound eye drops

In July 2006 , bimatoprost-timolol maleate compound eye drops developed by the United States company obtained approval from the European drug regulatory authority for reducing intraocular pressure or ocular hypertension of open-anglepatients glaucoma patients who do not respond adequately to the β-blockers or prostaglandin like treatment .
The compound eye drops containing 0.03% bimatoprost and 0.5% timolol maleate, once a day administration is able to provide clinically effective pressure control, the effect is better than single Bima latanoprost or timolol maleate. Clinical trials prove that the drug has an excellent tolerability, including the incidence of ocular hyperemia40% lower compared to single bimatoprost .

Chemical Properties

Crystalline Solid


Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.


Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2α.


Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha


Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.


17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is an F-series PG analog which has been approved for use as an ocular hypotensive drug. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.[Cayman Chemical]

Bimatoprost Preparation Products And Raw materials

Raw materials

Preparation Products

Bimatoprost Suppliers

Global( 200)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 China 887 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20811 55
Mainchem Co., Ltd.
0592-6210733 CHINA 3168 55
Shanghai finete Pharmaceutical Co., Ltd.
- CHINA 113 55
Taizhou Crene Biotechnology Co., Ltd. 0576-88813233 88205808
0576-88229589 China 100 57
Wuhan Kai Lun new material Chemical Co Ltd 025-87787262;15071332665
025-87787262 China 496 58
Lihe Wuhan New Chemical Materials Co., Ltd. 027-88395709,15071332665
027-88391805 China 426 50
Hubei Kangbaotai Finechem Co., Ltd. +86 (27) 8778653
+86 (27) 8773-8652 China 339 58
Chemvon Biotechnology Co., Ltd +86-21-50790412
+86-21-50790419 China 330 57

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